AC MF_00139; DC Protein; auto TR HAMAP; MF_00139; -; 1; level=0 XX Names: PurH XX ID PUR9 DE RecName: Full=Bifunctional purine biosynthesis protein PurH; DE Includes: DE RecName: Full=Phosphoribosylaminoimidazolecarboxamide formyltransferase; DE EC=2.1.2.3; DE AltName: Full=AICAR transformylase; DE Includes: DE RecName: Full=IMP cyclohydrolase; DE EC=3.5.4.10; DE AltName: Full=ATIC; DE AltName: Full=IMP synthase; DE AltName: Full=Inosinicase; GN Name=purH; XX CC -!- CATALYTIC ACTIVITY: CC Reaction=(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D- CC ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5- CC formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide; CC Xref=Rhea:RHEA:22192, ChEBI:CHEBI:57453, ChEBI:CHEBI:58467, CC ChEBI:CHEBI:58475, ChEBI:CHEBI:195366; EC=2.1.2.3; CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- CC carboxamide; Xref=Rhea:RHEA:18445, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:58053, ChEBI:CHEBI:58467; EC=3.5.4.10; CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5- CC formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino- CC 1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): CC step 1/1. CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; IMP CC from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step CC 1/1. CC -!- DOMAIN: The IMP cyclohydrolase activity resides in the N-terminal CC region. CC -!- SIMILARITY: Belongs to the PurH family. XX DR Pfam; PF01808; AICARFT_IMPCHas; 1; trigger=no DR Pfam; PF02142; MGS; 1; trigger=no DR NCBIfam; TIGR00355; PurH; 1; trigger=no DR PROSITE; PS51855; MGS; 1; trigger=yes XX case ( or ) and KW Acetylation end case KW Hydrolase KW Multifunctional enzyme KW Purine biosynthesis KW Transferase XX GO GO:0003937; F:IMP cyclohydrolase activity GO GO:0004643; F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity GO GO:0006189; P:'de novo' IMP biosynthetic process XX FT From: PUR9_ECOLI (P15639) case or FT MOD_RES 287 FT /note="N6-acetyllysine" FT Condition: K end case XX Size: 492-545; Related: None; Template: P31335; P31939; Scope: Bacteria Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: Divergent THEMA; sequence not included in alignment and not taken into account in size range XX # Revision 1.34 2023/07/18 //