AC   MF_00145;
DC   Protein; auto
TR   HAMAP; MF_00145; -; 1; level=0
XX
Names: Phosphoglyc_kinase
XX
ID   PGK
DE   RecName: Full=Phosphoglycerate kinase;
DE            EC=2.7.2.3;
GN   Name=pgk;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl
CC         phosphate + ADP; Xref=Rhea:RHEA:14801, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57604, ChEBI:CHEBI:58272, ChEBI:CHEBI:456216; EC=2.7.2.3;
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC       glyceraldehyde 3-phosphate: step 2/5.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the phosphoglycerate kinase family.
XX
DR   Pfam; PF00162; PGK; 1; trigger=no
DR   PRINTS; PR00477; PHGLYCKINASE; 1; trigger=no
DR   PROSITE; PS00111; PGLYCERATE_KINASE; 1; trigger=no
XX
case <FT:10>
KW   Acetylation
end case
KW   Cytoplasm
KW   ATP-binding
KW   Glycolysis
KW   Kinase
KW   Nucleotide-binding
KW   Transferase
case <FT:11> or <FT:12>
KW   Phosphoprotein
end case
XX
GO   GO:0004618; F:phosphoglycerate kinase activity
GO   GO:0006096; P:glycolytic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: PGKT_THEMA (P36204)
FT   BINDING         353..356
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G-G-[DEH]-[STAILFM]
FT   BINDING         21..23
FT                   /ligand="substrate"
FT   Condition: D-[LFMYVI]-N
FT   BINDING         59..62
FT                   /ligand="substrate"
FT   Condition: [HQR]-x-[GSDRK]-[RGKNDP]
FT   BINDING         36
FT                   /ligand="substrate"
FT   Optional; Condition: R
FT   BINDING         118
FT                   /ligand="substrate"
FT   Optional; Condition: R
FT   BINDING         151
FT                   /ligand="substrate"
FT   Optional; Condition: R
FT   BINDING         201
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: K
FT   BINDING         293
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: G
FT   BINDING         324
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: E
FT   From: PGK_ECOLI (P0A799)
case <OC:Escherichia> or <OC:Shigella>
FT   MOD_RES         84
FT                   /note="N6-acetyllysine"
FT   Condition: K
end case
FT   From: PGK_BACSU (P40924)
case <OC:Bacillaceae>
FT   MOD_RES         183
FT                   /note="Phosphoserine"
FT   Condition: S
FT   MOD_RES         299
FT                   /note="Phosphothreonine"
FT   Condition: T
end case
XX
Size: 385-419;
Related: None;
Template: P18912; Q8GIZ5; P36204; P09403; P61884;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: MF_00147 (tpiA); <Unknown>
Duplicate: in CUPNH, METAC
Plasmid: in CUPNH
Comments: None
XX
# Revision 1.39 2022/11/19
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