AC   MF_00151;
DC   Protein; auto
TR   HAMAP; MF_00151; -; 1; level=0
XX
Names: PPAT_bact
XX
ID   COAD
DE   RecName: Full=Phosphopantetheine adenylyltransferase;
DE            EC=2.7.7.3;
DE   AltName: Full=Dephospho-CoA pyrophosphorylase;
DE   AltName: Full=Pantetheine-phosphate adenylyltransferase;
DE            Short=PPAT;
GN   Name=coaD;
XX
CC   -!- FUNCTION: Reversibly transfers an adenylyl group from ATP to 4'-
CC       phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA +
CC         diphosphate; Xref=Rhea:RHEA:19801, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57328,
CC         ChEBI:CHEBI:61723; EC=2.7.7.3;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-
CC       pantothenate: step 4/5.
CC   -!- SUBUNIT: Homohexamer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the bacterial CoaD family.
XX
DR   Pfam; PF01467; CTP_transf_2; 1; trigger=no
DR   PRINTS; PR01020; LPSBIOSNTHSS; 1; trigger=no
DR   NCBIfam; TIGR01510; CoaD_prev_kdtB; 1; trigger=no
DR   NCBIfam; TIGR00125; Cyt_tran_rel; 1; trigger=no
XX
KW   ATP-binding
KW   Coenzyme A biosynthesis
KW   Cytoplasm
KW   Magnesium
KW   Nucleotide-binding
KW   Nucleotidyltransferase
KW   Transferase
XX
GO   GO:0004595; F:pantetheine-phosphate adenylyltransferase activity
GO   GO:0015937; P:coenzyme A biosynthetic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: COAD_ECOLI (P0A6I6)
FT   BINDING         10..11
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [TS]-[FYL]
FT   BINDING         89..91
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G-x-R
FT   BINDING         124..130
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   BINDING         10
FT                   /ligand="substrate"
FT   Condition: [TS]
FT   BINDING         18
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: H
FT   BINDING         42
FT                   /ligand="substrate"
FT   Condition: K
FT   BINDING         74
FT                   /ligand="substrate"
FT   Condition: [MLVIATS]
FT   BINDING         88
FT                   /ligand="substrate"
FT   Condition: [RK]
FT   BINDING         99
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: E
FT   SITE            18
FT                   /note="Transition state stabilizer"
FT   Condition: H
XX
Size: 140-191;
Related: None;
Template: P0A6I6; O26010; P9WPA5; P63820; Q8DNE6; O34797; Q3JW91; Q831P9; B7V2S6; P63819; Q9WZK0; Q5SJS9; Q8ZJN9;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Possible wrong start in ZYMMO
XX
# Revision 1.32 2023/06/01
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