AC   MF_00153;
DC   Protein; auto
TR   HAMAP; MF_00153; -; 1; level=0
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Names: DHS
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ID   DHYS
DE   RecName: Full=Probable deoxyhypusine synthase;
DE            Short=DHS;
DE            EC=2.5.1.46;
GN   Name=dys;
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CC   -!- FUNCTION: Catalyzes the NAD-dependent oxidative cleavage of spermidine
CC       and the subsequent transfer of the butylamine moiety of spermidine to
CC       the epsilon-amino group of a specific lysine residue of the eIF-5A
CC       precursor protein to form the intermediate deoxyhypusine residue.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-
CC         deoxyhypusine + propane-1,3-diamine; Xref=Rhea:RHEA:33299, Rhea:RHEA-
CC         COMP:10143, Rhea:RHEA-COMP:10144, ChEBI:CHEBI:29969,
CC         ChEBI:CHEBI:57484, ChEBI:CHEBI:57834, ChEBI:CHEBI:82657; EC=2.5.1.46;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC   -!- PATHWAY: Protein modification; eIF5A hypusination.
CC   -!- SIMILARITY: Belongs to the deoxyhypusine synthase family.
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DR   Pfam; PF01916; DS; 1; trigger=no
DR   NCBIfam; TIGR00321; Dhys; 1; trigger=no
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KW   Hypusine biosynthesis
KW   Transferase
KW   NAD
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GO   GO:0034038; F:deoxyhypusine synthase activity
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FT   From: DHYS_METJA (Q58224)
FT   ACT_SITE        303
FT                   /note="Nucleophile"
FT   Condition: K
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Size: 292-345;
Related: MF_00640;
Template: P49365; P38791; P49366;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in ARCFU, METAC, METMA
Plasmid: None
Comments: Probable wrong start in many cases
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# Revision 1.30 2023/06/01
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