AC   MF_00154;
DC   Protein; auto
TR   HAMAP; MF_00154; -; 1; level=0
XX
Names: CyoE_CtaB
XX
case <OC:Gammaproteobacteria>
ID   CYOE
else
ID   COXX
end case
DE   RecName: Full=Protoheme IX farnesyltransferase;
DE            EC=2.5.1.141;
DE   AltName: Full=Heme B farnesyltransferase;
DE   AltName: Full=Heme O synthase;
case <OC:Gammaproteobacteria>
GN   Name=cyoE;
else
GN   Name=ctaB;
end case
XX
CC   -!- FUNCTION: Converts heme B (protoheme IX) to heme O by substitution of
CC       the vinyl group on carbon 2 of heme B porphyrin ring with a
CC       hydroxyethyl farnesyl side group.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate +
CC         Fe(II)-heme o; Xref=Rhea:RHEA:28070, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:60344, ChEBI:CHEBI:60530,
CC         ChEBI:CHEBI:175763; EC=2.5.1.141;
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; heme O biosynthesis;
CC       heme O from protoheme: step 1/1.
case <OC:Bacillota> or <OC:Rhodobacterales>
CC   -!- SUBUNIT: Interacts with CtaA.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
end case
CC   -!- MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined
CC       according to the Fischer nomenclature.
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family. Protoheme IX
CC       farnesyltransferase subfamily.
XX
DR   Pfam; PF01040; UbiA; 1; trigger=no
DR   Pfam; PF02628; COX15-CtaA; 1; trigger=no
DR   NCBIfam; TIGR01473; CyoE_ctaB; 1; trigger=no
DR   PROSITE; PS00943; UBIA; 1; trigger=no
case not <OC:Escherichia> and not <OC:Shigella> and not <OC:Salmonella>
DR   General; Transmembrane; -; 0-9; trigger=yes
end case
XX
case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
KW   Cell membrane
KW   Heme biosynthesis
KW   Membrane
KW   Transferase
KW   Transmembrane
KW   Transmembrane helix
XX
GO   GO:0008495; F:protoheme IX farnesyltransferase activity
GO   GO:0048034; P:heme O biosynthetic process
GO   GO:0005886; C:plasma membrane
XX
FT   From: CYOE_ECOLI (P0AEA5)
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
FT   TOPO_DOM        Nter..9
FT                   /note="Cytoplasmic"
FT   TRANSMEM        10..28
FT                   /note="Helical"
FT   TOPO_DOM        29..37
FT                   /note="Periplasmic"
FT   TRANSMEM        38..56
FT                   /note="Helical"
FT   TOPO_DOM        57..78
FT                   /note="Cytoplasmic"
FT   TRANSMEM        79..97
FT                   /note="Helical"
FT   TOPO_DOM        98..107
FT                   /note="Periplasmic"
FT   TRANSMEM        108..126
FT                   /note="Helical"
FT   TOPO_DOM        127..197
FT                   /note="Cytoplasmic"
FT   TRANSMEM        198..216
FT                   /note="Helical"
FT   TOPO_DOM        217..228
FT                   /note="Periplasmic"
FT   TRANSMEM        229..247
FT                   /note="Helical"
FT   TOPO_DOM        248..268
FT                   /note="Cytoplasmic"
FT   TRANSMEM        269..287
FT                   /note="Helical"
FT   TOPO_DOM        288..Cter
FT                   /note="Periplasmic"
end case
XX
Size: 259-345;
Related: None;
Template: P24009; O31652; P0AEA5; Q3J5F9;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: <Unknown>; <COX15-CtaA>
 Cter: <Prenyltransferase>
Duplicate: in BACVZ, BACCN, BACSU, CENSY, CHRVO, LYSSC, MAGSA, NATPD, NITWN,
 PICTO, PSEA6, PSEA7, PSEAB, PSEAE, PSEE4, PSEF5, PSET1, PSEP1, PSEPF, PSEPG,
 PSEPK, PSEPW, PYRAE, PYRCJ, RHILO, SACEN, SHEB8, SHEB9, SHEFN, SHELP, SHEPC,
 SHESA, SHESM, SHESR, SHESW, SHEWM, VIBC1, VIBPA
Plasmid: None
Comments: Possible wrong start in RHOSH
XX
# Revision 1.48 2023/06/01
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