AC   MF_00161;
DC   Protein; auto
TR   HAMAP; MF_00161; -; 1; level=0
XX
Names: LspA
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ID   LSPA
DE   RecName: Full=Lipoprotein signal peptidase;
DE            EC=3.4.23.36;
DE   AltName: Full=Prolipoprotein signal peptidase;
DE   AltName: Full=Signal peptidase II;
DE            Short=SPase II;
GN   Name=lspA;
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CC   -!- FUNCTION: This protein specifically catalyzes the removal of signal
CC       peptides from prolipoproteins.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Release of signal peptides from bacterial membrane
CC         prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in
CC         which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and
CC         Zaa (Gly or Ala) have small, neutral side chains.; EC=3.4.23.36;
CC   -!- PATHWAY: Protein modification; lipoprotein biosynthesis (signal peptide
CC       cleavage).
case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
end case
CC   -!- SIMILARITY: Belongs to the peptidase A8 family.
XX
DR   Pfam; PF01252; Peptidase_A8; 1; trigger=no
DR   PRINTS; PR00781; LIPOSIGPTASE; 1; trigger=no
DR   NCBIfam; TIGR00077; LspA; 1; trigger=no
DR   PROSITE; PS00855; SPASE_II; 1; trigger=no
DR   General; Transmembrane; -; 4-5; trigger=yes
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KW   Hydrolase
KW   Protease
KW   Aspartyl protease
KW   Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
KW   Membrane
KW   Transmembrane
KW   Transmembrane helix
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GO   GO:0004190; F:aspartic-type endopeptidase activity
GO   GO:0005886; C:plasma membrane
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FT   From: LSPA_PSEAE (Q9HVM5)
FT   ACT_SITE        124
FT   Condition: D
FT   ACT_SITE        143
FT   Condition: D
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Size: 145-304;
Related: None;
Template: P00804; Q45479; Q9HVM5; Q2FHP2;
Scope:
 Bacteria
Fusion:
 Nter: <Unknown>
 Cter: None
Duplicate: in LISMO, STAES
Plasmid: in ARTAU, KLEPN, PSEND, PSEPU, RHOER, SERMA
Comments: None
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# Revision 1.43 2023/06/01
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