AC   MF_00164;
DC   Protein; auto
TR   HAMAP; MF_00164; -; 1; level=0
XX
Names: GlmS
XX
ID   GLMS
DE   RecName: Full=Glutamine--fructose-6-phosphate aminotransferase [isomerizing];
DE            EC=2.6.1.16;
DE   AltName: Full=D-fructose-6-phosphate amidotransferase;
DE   AltName: Full=GFAT;
DE   AltName: Full=Glucosamine-6-phosphate synthase;
DE   AltName: Full=Hexosephosphate aminotransferase;
DE   AltName: Full=L-glutamine--D-fructose-6-phosphate amidotransferase;
GN   Name=glmS;
XX
CC   -!- FUNCTION: Catalyzes the first step in hexosamine metabolism, converting
CC       fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-
CC         phosphate + L-glutamate; Xref=Rhea:RHEA:13237, ChEBI:CHEBI:29985,
CC         ChEBI:CHEBI:58359, ChEBI:CHEBI:58725, ChEBI:CHEBI:61527; EC=2.6.1.16;
CC   -!- SUBUNIT: Homodimer.
case <OG:Chloroplast>
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast.
end case
case not <OG:Chloroplast>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
end case
XX
DR   Pfam; PF00310; GATase_2; 1; trigger=no
DR   Pfam; PF01380; SIS; 2; trigger=yes
DR   NCBIfam; TIGR01135; GlmS; 1; trigger=no
DR   PROSITE; PS51278; GATASE_TYPE_2; 1; trigger=yes
DR   PROSITE; PS51464; SIS; 1-2; trigger=yes
XX
case not <OG:Chloroplast>
KW   Cytoplasm
end case
KW   Transferase
KW   Aminotransferase
XX
GO   GO:0004360; F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO   GO:0005975; P:carbohydrate metabolic process
case <OG:Chloroplast>
GO   GO:0009507; C:chloroplast
end case
case not <OG:Chloroplast>
GO   GO:0005737; C:cytoplasm
end case
XX
FT   From: GLMS_ECOLI (P17169)
FT   INIT_MET        1
FT                   /note="Removed"
FT   Condition: M
FT   ACT_SITE        2
FT                   /note="Nucleophile; for GATase activity"
FT   Condition: C
FT   ACT_SITE        604
FT                   /note="For Fru-6P isomerization activity"
FT   Condition: K
XX
Size: 589-635;
Related: None;
Template: P17169; Q56213; Q6LWM9;
Scope:
 Bacteria
 Archaea
 Plastid
Fusion:
 Nter: None
 Cter: None
Duplicate: in RHIME
Plasmid: in RHILV, RHIME
Comments: Nodulating bacteria seem to have two copies: a glmS and a nodM. There does
 not seem to be any mean of distinguishing the two forms.
 Intein deleted in METJA (not shown in alignment).
XX
# Revision 1.42 2023/06/01
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