AC MF_00165; DC Protein; auto TR HAMAP; MF_00165; -; 1; level=0 XX Names: Thymidylate_kinase XX ID KTHY case DE RecName: Full=Thymidylate kinase; DE EC=2.7.4.9; DE AltName: Full=dTMP kinase; end case case DE RecName: Full=Probable thymidylate kinase; DE EC=2.7.4.9; DE AltName: Full=dTMP kinase; end case GN Name=tmk; XX case CC -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and CC salvage pathways of dTTP synthesis. end case CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528, CC ChEBI:CHEBI:456216; EC=2.7.4.9; CC -!- SIMILARITY: Belongs to the thymidylate kinase family. XX DR Pfam; PF02223; Thymidylate_kin; 1; trigger=no DR NCBIfam; TIGR00041; DTMP_kinase; 1; trigger=no DR PROSITE; PS01331; THYMIDYLATE_KINASE; 1; trigger=no XX KW Transferase KW Kinase KW Nucleotide biosynthesis KW ATP-binding KW Nucleotide-binding XX GO GO:0005524; F:ATP binding GO GO:0004798; F:thymidylate kinase activity GO GO:0006235; P:dTTP biosynthetic process XX FT From: KTHY_ECOLI (P0A720) FT BINDING 10..17 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT Condition: G-x-[DE]-[GACT]-x-G-K-[ST] XX Size: 188-245; Related: None; Template: P0A720; P9WKE1; O69169; Scope: Bacteria Archaea Fusion: Nter: None Cter: None Duplicate: in SACS2, SULTO Plasmid: None Comments: Possible inactive tmk in AERPE and TREPA due to a defective ATP-binding site; not shown in alignment. Possible wrong start in RHOBA. XX # Revision 1.29 2023/06/01 //