AC   MF_00167;
DC   Protein; auto
TR   HAMAP; MF_00167; -; 1; level=0
XX
Names: CsrA
XX
ID   CSRA
case <OC:Gammaproteobacteria>
DE   RecName: Full=Translational regulator CsrA;
DE   AltName: Full=Carbon storage regulator;
else
DE   RecName: Full=Translational regulator CsrA;
end case
GN   Name=csrA;
XX
case <OC:Gammaproteobacteria>
CC   -!- FUNCTION: A key translational regulator that binds mRNA to regulate
CC       translation initiation and/or mRNA stability. Mediates global changes
CC       in gene expression, shifting from rapid growth to stress survival by
CC       linking envelope stress, the stringent response and the catabolite
CC       repression systems. Usually binds in the 5'-UTR; binding at or near the
CC       Shine-Dalgarno sequence prevents ribosome-binding, repressing
CC       translation, binding elsewhere in the 5'-UTR can activate translation
CC       and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
else
CC   -!- FUNCTION: A translational regulator that binds mRNA to regulate
CC       translation initiation and/or mRNA stability. Usually binds in the 5'-
CC       UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding,
CC       thus repressing translation. Its main target seems to be the major
CC       flagellin gene, while its function is anatagonized by FliW.
end case
CC   -!- SUBUNIT: Homodimer; the beta-strands of each monomer intercalate to
CC       form a hydrophobic core, while the alpha-helices form wings that extend
CC       away from the core.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the CsrA/RsmA family.
XX
DR   Pfam; PF02599; CsrA; 1; trigger=no
DR   NCBIfam; TIGR00202; CsrA; 1; trigger=no
XX
case <OC:Gammaproteobacteria>
KW   Activator
end case
case not <OC:Gammaproteobacteria>
KW   Bacterial flagellum biogenesis
end case
KW   Cytoplasm
KW   Repressor
KW   RNA-binding
KW   Translation regulation
XX
GO   GO:0005737; C:cytoplasm
GO   GO:0048027; F:mRNA 5'-UTR binding
GO   GO:0045947; P:negative regulation of translational initiation
case <OC:Gammaproteobacteria>
GO   GO:0006109; P:regulation of carbohydrate metabolic process
GO   GO:0045948; P:positive regulation of translational initiation
end case
case not <OC:Gammaproteobacteria>
GO   GO:1902208; P:regulation of bacterial-type flagellum assembly
end case
XX
FT   None
XX
Size: 57-135;
Related: None;
Template: P69913; P33911; O69078; P0DPC3;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in COXBU, PSESM
Plasmid: None
Comments: The ancestral operon is thought to be Fliw-CsrA, where CsrA is
 dedicated to controlling flagellar assembly and motility. Rounds of gene
 loss and re-acquisition in Gammaproteobacteria have lead to CsrA being
 repurposed for a larger role in translation control. See PubMed:25833324,
 Vakulskas et al., Microbiol. Mol. Biol. Rev. 79:193-224(2015) for a review.
XX
# Revision 1.23 2023/06/01
//