AC MF_00177; DC Protein; auto TR HAMAP; MF_00177; -; 1; level=0 XX Names: Lys_tRNA_synth_class1 XX ID SYK DE RecName: Full=Lysine--tRNA ligase; DE EC=6.1.1.6; DE AltName: Full=Lysyl-tRNA synthetase; DE Short=LysRS; GN Name=lysS; XX CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl- CC tRNA(Lys); Xref=Rhea:RHEA:20792, Rhea:RHEA-COMP:9696, Rhea:RHEA- CC COMP:9697, ChEBI:CHEBI:30616, ChEBI:CHEBI:32551, ChEBI:CHEBI:33019, CC ChEBI:CHEBI:78442, ChEBI:CHEBI:78529, ChEBI:CHEBI:456215; EC=6.1.1.6; CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family. XX DR Pfam; PF01921; tRNA-synt_1f; 1; trigger=no DR NCBIfam; TIGR00467; LysS_arch; 1; trigger=no DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1; trigger=no XX KW Cytoplasm KW Aminoacyl-tRNA synthetase KW Protein biosynthesis KW Ligase KW ATP-binding KW Nucleotide-binding XX GO GO:0005524; F:ATP binding GO GO:0004824; F:lysine-tRNA ligase activity GO GO:0006430; P:lysyl-tRNA aminoacylation GO GO:0005737; C:cytoplasm XX FT From: SYK_RICPR (Q9ZDF8) FT MOTIF 44..52 FT /note="'HIGH' region" FT Condition: [AIPTV]-S-G-x-[ILPQV]-H-[ILMV]-G-[HNRST] FT MOTIF 290..294 FT /note="'KMSKS' region" FT Condition: [ADKP]-[FILM]-[HKS]-[GKS]-S FT BINDING 293 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT Condition: K XX Size: 493-580; Related: None; Template: O57963; O51603; P0CW67; Scope: Bacteria Archaea Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: Lysyl-tRNA synthesis is catalyzed by two unrelated families of tRNA synthetase; class-I or class-II. Usually only one or the other is present, however Methanosarcina seem to have both. XX # Revision 1.36 2023/06/01 //