AC   MF_00182;
DC   Protein; auto
TR   HAMAP; MF_00182; -; 1; level=0
XX
Names: Formyl_trans
XX
ID   FMT
DE   RecName: Full=Methionyl-tRNA formyltransferase;
DE            EC=2.1.2.9;
GN   Name=fmt;
XX
CC   -!- FUNCTION: Attaches a formyl group to the free amino group of methionyl-
CC       tRNA(fMet). The formyl group appears to play a dual role in the
CC       initiator identity of N-formylmethionyl-tRNA by promoting its
CC       recognition by IF2 and preventing the misappropriation of this tRNA by
CC       the elongation apparatus.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6R)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) =
CC         (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-
CC         tRNA(fMet); Xref=Rhea:RHEA:24380, Rhea:RHEA-COMP:9952, Rhea:RHEA-
CC         COMP:9953, ChEBI:CHEBI:15378, ChEBI:CHEBI:57453, ChEBI:CHEBI:78530,
CC         ChEBI:CHEBI:78844, ChEBI:CHEBI:195366; EC=2.1.2.9;
CC   -!- SIMILARITY: Belongs to the Fmt family.
XX
DR   Pfam; PF02911; Formyl_trans_C; 1; trigger=no
DR   Pfam; PF00551; Formyl_trans_N; 1; trigger=no
DR   NCBIfam; TIGR00460; fmt; 1; trigger=no
DR   PROSITE; PS00373; GART; 1; trigger=no
XX
KW   Transferase
KW   Protein biosynthesis
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GO   GO:0004479; F:methionyl-tRNA formyltransferase activity
GO   GO:0019988; P:charged-tRNA amino acid modification
XX
FT   From: FMT_ECOLI (P23882)
FT   BINDING         113..116
FT                   /ligand="(6S)-5,6,7,8-tetrahydrofolate"
FT                   /ligand_id="ChEBI:CHEBI:57453"
FT   Condition: [GS]-x-L-P
XX
Size: 250-380;
Related: None;
Template: P23882;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Divergent RALN1 not shown in alignment
XX
# Revision 1.31 2023/11/28
//