AC   MF_00190;
DC   Protein; auto
TR   HAMAP; MF_00190; -; 1; level=0
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Names: Cardiolipin_synth_ClsA
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ID   CLSA
DE   RecName: Full=Cardiolipin synthase A;
DE            Short=CL synthase;
DE            EC=2.7.8.-;
GN   Name=clsA;
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CC   -!- FUNCTION: Catalyzes the reversible phosphatidyl group transfer from one
CC       phosphatidylglycerol molecule to another to form cardiolipin (CL)
CC       (diphosphatidylglycerol) and glycerol.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a
CC         cardiolipin + glycerol; Xref=Rhea:RHEA:31451, ChEBI:CHEBI:17754,
CC         ChEBI:CHEBI:62237, ChEBI:CHEBI:64716;
case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
end case
CC   -!- SIMILARITY: Belongs to the phospholipase D family. Cardiolipin synthase
CC       subfamily. ClsA sub-subfamily.
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DR   PROSITE; PS50035; PLD; 2; trigger=yes
DR   Pfam; PF13091; PLDc_2; 0-2; trigger=no
DR   Pfam; PF13396; PLDc_N; 0-1; trigger=no
DR   Pfam; PF00614; PLDc; 0-2; trigger=no
DR   NCBIfam; TIGR04265; bac_cardiolipin; 1; trigger=no
DR   General; Transmembrane; -; 2-3; trigger=yes
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case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
KW   Cell membrane
KW   Lipid biosynthesis
KW   Lipid metabolism
KW   Membrane
KW   Phospholipid biosynthesis
KW   Phospholipid metabolism
KW   Transferase
KW   Transmembrane
KW   Transmembrane helix
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GO   GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups
GO   GO:0008654; P:phospholipid biosynthetic process
GO   GO:0005886; C:plasma membrane
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FT   From: CLSA_ECOLI (P0A6H8)
FT   ACT_SITE        224
FT   Condition: H
FT   ACT_SITE        226
FT   Condition: K
FT   ACT_SITE        231
FT   Condition: D
FT   ACT_SITE        404
FT   Condition: H
FT   ACT_SITE        406
FT   Condition: K
FT   ACT_SITE        411
FT   Condition: D
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Size: 449-532;
Related: None;
Template: P0A6H8;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: This HAMAP is now restricted to the ClsA sub-subfamily (Pseudomonadota).
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# Revision 1.40 2023/06/01
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