AC   MF_00200;
DC   Protein; auto
TR   HAMAP; MF_00200; -; 1; level=0
XX
Names: RTC
XX
ID   RTCA
DE   RecName: Full=RNA 3'-terminal phosphate cyclase;
DE            Short=RNA cyclase;
DE            Short=RNA-3'-phosphate cyclase;
DE            EC=6.5.1.4;
GN   Name=rtcA;
XX
CC   -!- FUNCTION: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic
CC       phosphodiester at the end of RNA. The mechanism of action of the enzyme
CC       occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer
CC       of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of
CC       the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to
CC       produce the cyclic end product. The biological role of this enzyme is
CC       unknown but it is likely to function in some aspects of cellular RNA
CC       processing.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-
CC         cyclophospho-ribonucleotide-RNA + AMP + diphosphate;
CC         Xref=Rhea:RHEA:23976, Rhea:RHEA-COMP:10463, Rhea:RHEA-COMP:10464,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:83062,
CC         ChEBI:CHEBI:83064, ChEBI:CHEBI:456215; EC=6.5.1.4;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the RNA 3'-terminal cyclase family. Type 1
CC       subfamily.
XX
DR   PROSITE; PS01287; RTC; 1; trigger=no
DR   Pfam; PF01137; RTC; 1; trigger=no
DR   NCBIfam; TIGR03399; RNA_3prim_cycl; 1; trigger=no
XX
KW   ATP-binding
KW   Cytoplasm
KW   Ligase
KW   Nucleotide-binding
XX
GO   GO:0003963; F:RNA-3'-phosphate cyclase activity
GO   GO:0005737; C:cytoplasm
XX
FT   From: RTCA_ECOLI (P46849)
FT   BINDING         283..287
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [YHF]-x-x-D-[QH]
FT   ACT_SITE        308
FT                   /note="Tele-AMP-histidine intermediate"
FT   Condition: H
FT   BINDING         103
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [QD]
XX
Size: 319-400;
Related: None;
Template: P46849;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Generally, RNA 3'-terminal phosphate cyclases are ATP dependent, but P.furiosus
 enzyme preferentially uses GTP rather than ATP (PubMed:22074260).
XX
# Revision 1.30 2023/06/01
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