AC   MF_00204;
DC   Protein; auto
TR   HAMAP; MF_00204; -; 1; level=0
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Names: UvrB
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ID   UVRB
DE   RecName: Full=UvrABC system protein B;
DE            Short=Protein UvrB;
DE   AltName: Full=Excinuclease ABC subunit B;
GN   Name=uvrB;
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CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. A damage recognition complex composed of 2
CC       UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of
CC       the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps
CC       around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB
CC       and probably causes local melting of the DNA helix, facilitating
CC       insertion of UvrB beta-hairpin between the DNA strands. Then UvrB
CC       probes one DNA strand for the presence of a lesion. If a lesion is
CC       found the UvrA subunits dissociate and the UvrB-DNA preincision complex
CC       is formed. This complex is subsequently bound by UvrC and the second
CC       UvrB is released. If no lesion is found, the DNA wraps around the other
CC       UvrB subunit that will check the other stand for damage.
CC   -!- SUBUNIT: Forms a heterotetramer with UvrA during the search for
CC       lesions. Interacts with UvrC in an incision complex.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- DOMAIN: The beta-hairpin motif is involved in DNA binding.
CC   -!- SIMILARITY: Belongs to the UvrB family.
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DR   Pfam; PF00271; Helicase_C; 1; trigger=no
DR   Pfam; PF04851; ResIII; 1; trigger=no
DR   Pfam; PF02151; UVR; 1; trigger=no
DR   NCBIfam; TIGR00631; Uvrb; 1; trigger=no
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1; trigger=yes
DR   PROSITE; PS51194; HELICASE_CTER; 1; trigger=yes
DR   PROSITE; PS50151; UVR; 0-1; trigger=yes
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KW   Cytoplasm
KW   DNA damage
KW   SOS response
KW   Excision nuclease
KW   DNA repair
KW   DNA excision
KW   ATP-binding
KW   Nucleotide-binding
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GO   GO:0005524; F:ATP binding
GO   GO:0003677; F:DNA binding
GO   GO:0009381; F:excinuclease ABC activity
GO   GO:0006281; P:DNA repair
GO   GO:0006289; P:nucleotide-excision repair
GO   GO:0009432; P:SOS response
GO   GO:0005737; C:cytoplasm
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FT   From: UVRB_ECOLI (P0A8F8)
FT   BINDING         39..46
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G-[IVAT]-T-G-[ST]-G-K-[ST]
FT   MOTIF           92..115
FT                   /note="Beta-hairpin"
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Size: 645-709;
Related: None;
Template: P56981; P0A8F8; Q56243;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.37 2023/06/01
//