AC   MF_00205;
DC   Protein; auto
TR   HAMAP; MF_00205; -; 1; level=0
XX
Names: UvrA
XX
ID   UVRA
DE   RecName: Full=UvrABC system protein A;
DE            Short=UvrA protein;
DE   AltName: Full=Excinuclease ABC subunit A;
GN   Name=uvrA;
XX
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC       A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC       scans DNA for abnormalities. When the presence of a lesion has been
CC       verified by UvrB, the UvrA molecules dissociate.
CC   -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC       lesions.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
XX
DR   Pfam; PF00005; ABC_tran; 1; trigger=no
DR   NCBIfam; TIGR00630; Uvra; 1; trigger=no
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1-2; trigger=no
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1-2; trigger=no
XX
KW   Cytoplasm
KW   DNA damage
KW   SOS response
KW   Excision nuclease
KW   DNA repair
KW   DNA excision
KW   ATP-binding
KW   Nucleotide-binding
KW   DNA-binding
KW   Repeat
case <FTTag:zinc>
KW   Metal-binding
KW   Zinc
KW   Zinc-finger
end case
XX
GO   GO:0005524; F:ATP binding
GO   GO:0003677; F:DNA binding
GO   GO:0009381; F:excinuclease ABC activity
case <FTTag:zinc>
GO   GO:0008270; F:zinc ion binding
end case
GO   GO:0006281; P:DNA repair
GO   GO:0006289; P:nucleotide-excision repair
GO   GO:0009432; P:SOS response
GO   GO:0005737; C:cytoplasm
XX
FT   From: UVRA_ECOLI (P0A698)
FT   DOMAIN          310..587
FT                   /note="ABC transporter 1"
FT   DOMAIN          607..937
FT                   /note="ABC transporter 2"
FT   BINDING         31..38
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G-x-S-G-S-G-K-S
FT   ZN_FING         253..280
FT                   /note="C4-type"
FT   Tag: zinc; Condition: C-x(2,3)-[CH]-x(20)-C-x(2)-C
FT   BINDING         640..647
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G-x-S-G-[GS]-G-K-S
FT   ZN_FING         740..766
FT                   /note="C4-type"
FT   Tag: zinc; Condition: C-x(2)-C-x(19)-C-x(2)-C
XX
Size: 900-1100;
Related: None;
Template: P0A698;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Internal duplication in CHLPN and CHLTR. These sequences were not used in
 the alignment as both half of these sequences are divergent compared to
 other uvrA
XX
# Revision 1.38 2023/06/01
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