AC   MF_00217;
DC   Protein; auto
TR   HAMAP; MF_00217; -; 1; level=0
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Names: Mevalonate_kinase
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ID   MVK
DE   RecName: Full=Mevalonate kinase;
DE            Short=MK;
DE            Short=MVK;
DE            EC=2.7.1.36;
GN   Name=mvk;
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CC   -!- FUNCTION: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-
CC       mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA)
CC       pathway leading to isopentenyl diphosphate (IPP), a key precursor for
CC       the biosynthesis of isoprenoid compounds such as archaeal membrane
CC       lipids.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+);
CC         Xref=Rhea:RHEA:17065, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:36464, ChEBI:CHEBI:58146, ChEBI:CHEBI:456216;
CC         EC=2.7.1.36;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis
CC       via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate:
CC       step 1/3.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. Mevalonate kinase
CC       subfamily.
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DR   Pfam; PF08544; GHMP_kinases_C; 1; trigger=no
DR   Pfam; PF00288; GHMP_kinases_N; 1; trigger=no
DR   PRINTS; PR00959; MEVGALKINASE; 1; trigger=no
DR   NCBIfam; TIGR00549; Mevalon_kin; 1; trigger=no
DR   PROSITE; PS00627; GHMP_KINASES_ATP; 1; trigger=no
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KW   Cytoplasm
KW   Transferase
KW   Kinase
KW   ATP-binding
KW   Nucleotide-binding
KW   Magnesium
KW   Isoprene biosynthesis
KW   Lipid biosynthesis
KW   Lipid metabolism
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GO   GO:0005524; F:ATP binding
GO   GO:0000287; F:magnesium ion binding
GO   GO:0004496; F:mevalonate kinase activity
GO   GO:0008299; P:isoprenoid biosynthetic process
GO   GO:0005737; C:cytoplasm
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FT   From: MVK_METJA (Q58487)
FT   BINDING         104..114
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: P-x(3)-G-L-G-S-S-A-[SA]
FT   ACT_SITE        155
FT                   /note="Proton acceptor"
FT   Condition: D
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Size: 284-337;
Related: MF_00384;
Template: Q58487; Q980D2;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.27 2023/06/01
//