AC   MF_00218;
DC   Protein; auto
TR   HAMAP; MF_00218; -; 1; level=0
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Names: URO_D
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ID   DCUP
DE   RecName: Full=Uroporphyrinogen decarboxylase;
DE            Short=UPD;
DE            Short=URO-D;
DE            EC=4.1.1.37;
GN   Name=hemE;
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CC   -!- FUNCTION: Catalyzes the decarboxylation of four acetate groups of
CC       uroporphyrinogen-III to yield coproporphyrinogen-III.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen
CC         III; Xref=Rhea:RHEA:19865, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:57308, ChEBI:CHEBI:57309; EC=4.1.1.37;
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen decarboxylase family.
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DR   PROSITE; PS00906; UROD_1; 1; trigger=no
DR   PROSITE; PS00907; UROD_2; 1; trigger=no
DR   Pfam; PF01208; URO-D; 1; trigger=no
DR   NCBIfam; TIGR01464; HemE; 1; trigger=no
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KW   Cytoplasm
KW   Lyase
KW   Decarboxylase
KW   Porphyrin biosynthesis
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GO   GO:0004853; F:uroporphyrinogen decarboxylase activity
GO   GO:0006779; P:porphyrin-containing compound biosynthetic process
GO   GO:0005737; C:cytoplasm
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FT   From: DCUP_BACSU (P32395)
FT   BINDING         29..33
FT                   /ligand="substrate"
FT   Condition: R-x-[AVS]-x-R
FT   BINDING         48
FT                   /ligand="substrate"
FT   Optional; Condition: F
FT   BINDING         78
FT                   /ligand="substrate"
FT   Condition: D
FT   BINDING         154
FT                   /ligand="substrate"
FT   Condition: Y
FT   BINDING         209
FT                   /ligand="substrate"
FT   Condition: [ST]
FT   BINDING         322
FT                   /ligand="substrate"
FT   Condition: H
FT   SITE            78
FT                   /note="Transition state stabilizer"
FT   Condition: D
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Size: 324-385;
Related: None;
Template: P32395; P32920; P06132;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.37 2023/06/01
//