AC MF_00227; DC Protein; auto TR HAMAP; MF_00227; -; 1; level=0 XX Names: RNase_P XX ID RNPA DE RecName: Full=Ribonuclease P protein component; DE Short=RNase P protein; DE Short=RNaseP protein; DE EC=3.1.26.5; DE AltName: Full=Protein C5; GN Name=rnpA; XX CC -!- FUNCTION: RNaseP catalyzes the removal of the 5'-leader sequence from CC pre-tRNA to produce the mature 5'-terminus. It can also cleave other CC RNA substrates such as 4.5S RNA. The protein component plays an CC auxiliary but essential role in vivo by binding to the 5'-leader CC sequence and broadening the substrate specificity of the ribozyme. CC -!- CATALYTIC ACTIVITY: CC Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides CC from tRNA precursor.; EC=3.1.26.5; CC -!- SUBUNIT: Consists of a catalytic RNA component (M1 or rnpB) and a CC protein subunit. CC -!- SIMILARITY: Belongs to the RnpA family. XX DR Pfam; PF00825; Ribonuclease_P; 1; trigger=no DR NCBIfam; TIGR00188; RnpA; 1; trigger=no DR PROSITE; PS00648; RIBONUCLEASE_P; 1; trigger=no XX KW Hydrolase KW Nuclease KW Endonuclease KW tRNA processing KW RNA-binding XX GO GO:0004526; F:ribonuclease P activity GO GO:0000049; F:tRNA binding GO GO:0001682; P:tRNA 5'-leader removal XX FT None XX Size: 108-166; Related: None; Template: P25814; P0A0H5; Scope: Bacteria Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.22 2023/06/01 //