AC   MF_00228;
DC   Protein; auto
TR   HAMAP; MF_00228; -; 1; level=0
XX
Names: Thz_kinase
XX
ID   THIM
DE   RecName: Full=Hydroxyethylthiazole kinase;
DE            EC=2.7.1.50;
DE   AltName: Full=4-methyl-5-beta-hydroxyethylthiazole kinase;
DE            Short=TH kinase;
DE            Short=Thz kinase;
GN   Name=thiM;
XX
CC   -!- FUNCTION: Catalyzes the phosphorylation of the hydroxyl group of 4-
CC       methyl-5-beta-hydroxyethylthiazole (THZ).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-
CC         phosphooxyethyl)-thiazole + ADP + H(+); Xref=Rhea:RHEA:24212,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17957, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:58296, ChEBI:CHEBI:456216; EC=2.7.1.50;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-
CC       methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-
CC       methylthiazole: step 1/1.
CC   -!- SIMILARITY: Belongs to the Thz kinase family.
XX
DR   Pfam; PF02110; HK; 1; trigger=no
DR   PRINTS; PR01099; HYETHTZKNASE; 1; trigger=no
DR   NCBIfam; TIGR00694; ThiM; 1; trigger=no
XX
KW   Magnesium
KW   Metal-binding
KW   Thiamine biosynthesis
KW   Transferase
KW   Kinase
KW   ATP-binding
KW   Nucleotide-binding
XX
GO   GO:0000287; F:magnesium ion binding
GO   GO:0005524; F:ATP binding
GO   GO:0004417; F:hydroxyethylthiazole kinase activity
XX
FT   From: THIM_BACSU (P39593)
FT   BINDING         45
FT                   /ligand="substrate"
FT   Condition: M
FT   BINDING         121
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   BINDING         168
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [ST]
FT   BINDING         195
FT                   /ligand="substrate"
FT   Condition: [GA]
XX
Size: 220-320;
Related: None;
Template: P39593;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: MF_00097 (thiE)
Duplicate: in CLOB1, CLOB6, CLOBH, CLOBJ, CLOBK, CLOBL, CLOBM, LEUMM, METST,
 OCEIH, STRP2, STRP4, STRP7, STRPI, STRPJ, STRPN, STRPS, STRR6, STRZJ, STRZP,
 STRZT
Plasmid: in RHIE6, RHIEC, RHIJ3, RHILW
Comments: AGRFC has internal deletion; not shown in alignment or used in size range.
 Fusion with thiE in SYMTH.
XX
# Revision 1.44 2023/11/28
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