AC   MF_00241;
DC   Protein; auto
TR   HAMAP; MF_00241; -; 1; level=0
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Names: Ogg
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ID   OGG1
DE   RecName: Full=8-oxoguanine DNA glycosylase/AP lyase;
DE   Includes:
DE     RecName: Full=8-oxoguanine DNA glycosylase;
DE              Short=8-oxoG DNA glycosylase;
DE              EC=3.2.2.-;
DE   Includes:
DE     RecName: Full=DNA-(apurinic or apyrimidinic site) lyase;
DE              Short=AP lyase;
DE              EC=4.2.99.18;
GN   Name=ogg;
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CC   -!- FUNCTION: Catalyzes the excision of an oxidatively damaged form of
CC       guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the
CC       DNA backbone at apurinic/apyrimidinic sites (AP sites).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-
CC         deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-
CC         dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-
CC         deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:66592, Rhea:RHEA-
CC         COMP:13180, Rhea:RHEA-COMP:16897, Rhea:RHEA-COMP:17067,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:157695,
CC         ChEBI:CHEBI:167181; EC=4.2.99.18;
CC   -!- SIMILARITY: Belongs to the type-2 OGG1 family.
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DR   PIRSF; PIRSF005954; Thrmst_ogg; 1; trigger=no
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KW   DNA damage
KW   DNA repair
KW   Glycosidase
KW   Hydrolase
KW   Lyase
KW   Multifunctional enzyme
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GO   GO:0003906; F:DNA-(apurinic or apyrimidinic site) endonuclease activity
GO   GO:0016799; F:hydrolase activity, hydrolyzing N-glycosyl compounds
GO   GO:0006284; P:base-excision repair
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FT   From: OGG1_METJA (Q58134)
FT   ACT_SITE        129
FT   Condition: K
FT   ACT_SITE        147
FT   Condition: D
FT   SITE            Cter
FT                   /note="Important for guanine/8-oxoguanine distinction"
FT   Condition: K
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Size: 170-270;
Related: None;
Template: Q58134; O29876; Q97CP1; Q97ZK2;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.25 2024/01/30
//