AC   MF_00246;
DC   Protein; auto
TR   HAMAP; MF_00246; -; 1; level=0
XX
Names: Galactokinase
XX
ID   GAL1
DE   RecName: Full=Galactokinase;
DE            EC=2.7.1.6;
DE   AltName: Full=Galactose kinase;
GN   Name=galK;
XX
CC   -!- FUNCTION: Catalyzes the transfer of the gamma-phosphate of ATP to D-
CC       galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate
CC         + H(+); Xref=Rhea:RHEA:13553, ChEBI:CHEBI:15378, ChEBI:CHEBI:28061,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58336, ChEBI:CHEBI:456216; EC=2.7.1.6;
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. GalK subfamily.
XX
DR   Pfam; PF10509; GalKase_gal_bdg; 1; trigger=no
DR   Pfam; PF08544; GHMP_kinases_C; 1; trigger=no
DR   Pfam; PF00288; GHMP_kinases_N; 1; trigger=no
DR   PIRSF; PIRSF000530; Galactokinase; 1; trigger=no
DR   PRINTS; PR00473; GALCTOKINASE; 1; trigger=no
DR   PRINTS; PR00959; MEVGALKINASE; 1; trigger=no
DR   NCBIfam; TIGR00131; Gal_kin; 1; trigger=no
DR   PROSITE; PS00106; GALACTOKINASE; 1; trigger=no
DR   PROSITE; PS00627; GHMP_KINASES_ATP; 1; trigger=no
XX
KW   ATP-binding
KW   Carbohydrate metabolism
KW   Cytoplasm
KW   Galactose metabolism
KW   Kinase
KW   Magnesium
KW   Metal-binding
KW   Nucleotide-binding
KW   Transferase
XX
GO   GO:0000287; F:magnesium ion binding
GO   GO:0005524; F:ATP binding
GO   GO:0004335; F:galactokinase activity
GO   GO:0006012; P:galactose metabolic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: GAL1_PYRFU (Q9HHB6)
FT   BINDING         101..107
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [GAS]-[AS]-[GS]-x-S-S-S
FT   BINDING         17..20
FT                   /ligand="substrate"
FT   Condition: E-[HY]-x-D
FT   ACT_SITE        151
FT                   /note="Proton acceptor"
FT   Condition: D
FT   BINDING         107
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: S
FT   BINDING         139
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: E
FT   BINDING         49
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: S
FT   BINDING         200
FT                   /ligand="substrate"
FT   Condition: Y
FT   SITE            11
FT                   /note="Transition state stabilizer"
FT   Condition: R
XX
Size: 350-399;
Related: None;
Template: P0A6T3; Q9HHB6; Q9R7D7; O58107;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Divergent galK in TREPA: TP0418; not included in alignment
XX
# Revision 1.33 2023/06/01
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