AC MF_00260; DC Protein; auto TR HAMAP; MF_00260; -; 1; level=0 XX Names: Porphobil_deam XX ID HEM3 case DE RecName: Full=Porphobilinogen deaminase; DE Short=PBG; DE EC=2.5.1.61; DE AltName: Full=Hydroxymethylbilane synthase; DE Short=HMBS; DE AltName: Full=Pre-uroporphyrinogen synthase; end case case DE RecName: Full=Probable porphobilinogen deaminase; DE Short=PBG; DE EC=2.5.1.61; DE AltName: Full=Hydroxymethylbilane synthase; DE Short=HMBS; DE AltName: Full=Pre-uroporphyrinogen synthase; end case GN Name=hemC; XX CC -!- FUNCTION: Tetrapolymerization of the monopyrrole PBG into the CC hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+); CC Xref=Rhea:RHEA:13185, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, CC ChEBI:CHEBI:57845, ChEBI:CHEBI:58126; EC=2.5.1.61; CC -!- COFACTOR: CC Name=dipyrromethane; Xref=ChEBI:CHEBI:60342; CC Note=Binds 1 dipyrromethane group covalently.; case not CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4. end case case CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4. CC -!- PATHWAY: Porphyrin-containing compound metabolism; chlorophyll CC biosynthesis. end case case CC -!- SUBUNIT: Monomer. end case CC -!- MISCELLANEOUS: The porphobilinogen subunits are added to the CC dipyrromethane group. CC -!- SIMILARITY: Belongs to the HMBS family. XX DR Pfam; PF01379; Porphobil_deam; 1; trigger=no DR PRINTS; PR00151; PORPHBDMNASE; 1; trigger=no DR NCBIfam; TIGR00212; HemC; 1; trigger=no DR PROSITE; PS00533; PORPHOBILINOGEN_DEAM; 1; trigger=no XX KW Porphyrin biosynthesis case KW Chlorophyll biosynthesis end case KW Transferase XX GO GO:0004418; F:hydroxymethylbilane synthase activity case GO GO:0015995; P:chlorophyll biosynthetic process end case GO GO:0006779; P:porphyrin-containing compound biosynthetic process XX FT From: HEM3_ECOLI (P06983) FT MOD_RES 242 FT /note="S-(dipyrrolylmethanemethyl)cysteine" FT Condition: C XX Size: 282-395; Related: None; Template: P06983; Scope: Bacteria Archaea Fusion: Nter: None Cter: None Duplicate: in STRAW, STRCO Plasmid: None Comments: Chlamydial hemC are divergent and lack the cofactor binding site, they are shorter and they have not been included in the alignment. HALSA and PAEMA have atypical inserts. RPE1 type insert in RICCN. XX # Revision 1.40 2023/06/01 //