AC   MF_00265;
DC   Protein; auto
TR   HAMAP; MF_00265; -; 1; level=0
XX
Names: VapC/Nob1
XX
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
ID   VAPC
DE   RecName: Full=tRNA(fMet)-specific endonuclease VapC;
DE            EC=3.1.-.-;
DE   AltName: Full=RNase VapC;
DE   AltName: Full=Toxin VapC;
GN   Name=vapC;
else case <OC:Bacteria>
ID   VAPC
DE   RecName: Full=Ribonuclease VapC;
DE            Short=RNase VapC;
DE            EC=3.1.-.-;
DE   AltName: Full=Toxin VapC;
GN   Name=vapC;
else case <OC:Archaea>
ID   VAPC
DE   RecName: Full=Ribonuclease VapC;
DE            Short=RNase VapC;
DE            EC=3.1.-.-;
DE   AltName: Full=Putative toxin VapC;
GN   Name=vapC;
end case
XX
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
CC   -!- FUNCTION: Toxic component of a toxin-antitoxin (TA) system. A site-
CC       specific tRNA-(fMet) endonuclease, it cleaves both charged and
CC       uncharged tRNA-(fMet) between positions 38 and 39 at the anticodon
CC       stem-loop boundary. Its toxic effects are neutralized by expression of
CC       cognate antitoxin VapB.
else
CC   -!- FUNCTION: Toxic component of a toxin-antitoxin (TA) system. An RNase.
end case
case <FT:1> or <FT:2>
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
end case
CC   -!- SIMILARITY: Belongs to the PINc/VapC protein family.
XX
DR   Pfam; PF01850; PIN; 0-1; trigger=yes
case not <Feature:PF01850>
DR   SMART; SM00670; PINc; 0-1; trigger=yes
end case
XX
KW   Toxin-antitoxin system
case <FT:1> or <FT:2>
KW   Magnesium
KW   Metal-binding
end case
KW   Hydrolase
KW   Nuclease
KW   Toxin
XX
case <FT:1> or <FT:2>
GO   GO:0000287; F:magnesium ion binding
end case
XX
FT   From: VAPC1_AQUAE (O66399)
FT   BINDING         9
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Optional; Condition: D
FT   BINDING         102
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Optional; Condition: D
XX
Size: 112-197;
Related: None;
Template: Q8ZM86; O06662; P9WFB7; P9WF85; P9WFB9; O58440;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: <Leu-rich domain>
 Cter: <TRAM domain>
Duplicate: in ARCFU, HAEIN, METJA, MYCBO, MYCTU, PYRAE, PYRHO
Plasmid: in AQUAE, METJA, PSESM, SINFN
Comments: VAPC1_THEAC and NOB1_METJA may be too long at N-terminus.
 Y540_THEAC fused with a Leu-rich transmembrane domain at N-terminus and
 TRAM domain at C-terminus, several other proteins are also fused to a TRAM
 domain. VAPC8_MYCTU atypical sequence. VAPC3_METJA, VPC14_MYCTU too short.
 At least 1 zinc-binding archaeal member processes pre-16S rRNA
 (NOB1_PYRHO, O58440); archaeal members that have the ability to bind zinc
 in the C-termini have been accordingly reannotated.
XX
# Revision 1.32 2022/11/19
//