AC   MF_00278;
DC   Protein; auto
TR   HAMAP; MF_00278; -; 1; level=0
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Names: HisH
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ID   HIS5
DE   RecName: Full=Imidazole glycerol phosphate synthase subunit HisH;
DE            EC=4.3.2.10;
DE   AltName: Full=IGP synthase glutaminase subunit;
DE            EC=3.5.1.2;
DE   AltName: Full=IGP synthase subunit HisH;
DE   AltName: Full=ImGP synthase subunit HisH;
DE            Short=IGPS subunit HisH;
GN   Name=hisH;
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CC   -!- FUNCTION: IGPS catalyzes the conversion of PRFAR and glutamine to IGP,
CC       AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of
CC       glutamine to glutamate and ammonia as part of the synthesis of IGP and
CC       AICAR. The resulting ammonia molecule is channeled to the active site
CC       of HisF.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-
CC         phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-
CC         amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-
CC         erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate;
CC         Xref=Rhea:RHEA:24793, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985,
CC         ChEBI:CHEBI:58278, ChEBI:CHEBI:58359, ChEBI:CHEBI:58475,
CC         ChEBI:CHEBI:58525; EC=4.3.2.10;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC         Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.
CC   -!- SUBUNIT: Heterodimer of HisH and HisF.
case <OG:Chloroplast>
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast.
else
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
end case
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DR   Pfam; PF00117; GATase; 1; trigger=no
DR   PRINTS; PR00096; GATASE; 1; trigger=no
DR   NCBIfam; TIGR01855; IMP_synth_hisH; 1; trigger=no
DR   PROSITE; PS51273; GATASE_TYPE_1; 1; trigger=yes
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case not <OG:Chloroplast>
KW   Cytoplasm
end case
KW   Amino-acid biosynthesis
KW   Histidine biosynthesis
KW   Hydrolase
KW   Glutamine amidotransferase
KW   Lyase
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GO   GO:0000107; F:imidazoleglycerol-phosphate synthase activity
GO   GO:0000105; P:histidine biosynthetic process
case <OG:Chloroplast>
GO   GO:0009507; C:chloroplast
else
GO   GO:0005737; C:cytoplasm
end case
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FT   From: HIS5_THEMA (Q9X0C8)
FT   ACT_SITE        84
FT                   /note="Nucleophile"
FT   Condition: C
FT   ACT_SITE        178
FT   Condition: H
FT   ACT_SITE        180
FT   Condition: E
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Size: 186-242;
Related: None;
Template: P60595; Q9X0C8; Q7SIC0;
Scope:
 Bacteria
 Archaea
 Plastid
Fusion:
 Nter: None
 Cter: None
Duplicate: in CAMJE, CAMJR, LEGPA, LEGPH, LEGPL, NITWN, PROMM, PSEAE, PARMW,
 VIBVY, METMP
Plasmid: None
Comments: AZOBR seems to lack an internal segment that contains the Cys active site;
 not shown in alignment
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# Revision 1.49 2023/06/01
//