AC   MF_00288;
DC   Protein; auto
TR   HAMAP; MF_00288; -; 1; level=0
XX
Names: MetE
XX
ID   METE
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
DE   RecName: Full=Methionine synthase;
DE            EC=2.1.1.-;
DE   AltName: Full=Homocysteine methyltransferase;
DE   AltName: Full=Methylcobalamin:homocysteine methyltransferase;
else
DE   RecName: Full=Methionine synthase;
DE            EC=2.1.1.-;
DE   AltName: Full=Homocysteine methyltransferase;
end case
GN   Name=metE;
XX
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
CC   -!- FUNCTION: Catalyzes the transfer of a methyl group to L-homocysteine
CC       resulting in methionine formation. Can use methylcobalamin and
CC       methylcobinamide as methyl donors, but methylcobalamin is not
CC       considered to be the physiological substrate.
else
CC   -!- FUNCTION: Catalyzes the transfer of a methyl group to L-homocysteine
CC       resulting in methionine formation. The physiological methyl donor is
CC       unknown.
end case
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo
CC       pathway.
CC   -!- SIMILARITY: Belongs to the archaeal MetE family.
XX
DR   Pfam; PF01717; Meth_synt_2; 1; trigger=no
XX
KW   Transferase
KW   Methyltransferase
KW   Amino-acid biosynthesis
KW   Methionine biosynthesis
KW   Metal-binding
KW   Zinc
XX
GO   GO:0008168; F:methyltransferase activity
GO   GO:0009086; P:methionine biosynthetic process
XX
FT   From: METE_METTM (P55299)
FT   BINDING         201
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Condition: H
FT   BINDING         203
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Condition: C
FT   BINDING         224
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Optional; Condition: E
FT   BINDING         285
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Condition: C
XX
Size: 308-344;
Related: MF_00172;
Template: P55299;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.30 2022/11/19
//