AC   MF_00290;
DC   Protein; auto
TR   HAMAP; MF_00290; -; 1; level=0
XX
Names: tRNA_dimethyltr_TRM1
XX
ID   TRM1
case <OC:Archaea>
DE   RecName: Full=tRNA (guanine(26)-N(2))-dimethyltransferase;
DE            EC=2.1.1.216;
DE   AltName: Full=tRNA 2,2-dimethylguanosine-26 methyltransferase;
DE   AltName: Full=tRNA(guanine-26,N(2)-N(2)) methyltransferase;
DE   AltName: Full=tRNA(m(2,2)G26)dimethyltransferase;
end case
case <OC:Bacteria>
DE   RecName: Full=tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase;
DE            EC=2.1.1.215;
end case
GN   Name=trm1;
XX
case <OC:Archaea>
CC   -!- FUNCTION: Dimethylates a single guanine residue at position 26 of a
CC       number of tRNAs using S-adenosyl-L-methionine as donor of the methyl
CC       groups.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-
CC         dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+);
CC         Xref=Rhea:RHEA:43140, Rhea:RHEA-COMP:10359, Rhea:RHEA-COMP:10360,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74269, ChEBI:CHEBI:74513; EC=2.1.1.216;
end case
case <OC:Bacteria>
CC   -!- FUNCTION: Dimethylates the guanine residues at position 26 and 27 of
CC       one or more tRNAs using S-adenosyl-L-methionine as donor of the methyl
CC       groups.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-
CC         methionine = N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in
CC         tRNA + 4 S-adenosyl-L-homocysteine + 4 H(+); Xref=Rhea:RHEA:43136,
CC         Rhea:RHEA-COMP:10353, Rhea:RHEA-COMP:10354,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74269, ChEBI:CHEBI:74513; EC=2.1.1.215;
end case
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. Trm1 family.
XX
DR   Pfam; PF02005; TRM; 1; trigger=no
DR   NCBIfam; TIGR00308; TRM1; 1; trigger=no
DR   PROSITE; PS51626; SAM_MT_TRM1; 1; trigger=yes
XX
KW   Methyltransferase
KW   RNA-binding
KW   S-adenosyl-L-methionine
KW   Transferase
KW   tRNA processing
KW   tRNA-binding
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
XX
GO   GO:0160104; F:tRNA (guanine(26)-N2)-dimethyltransferase activity
GO   GO:0030488; P:tRNA methylation
XX
FT   From: TRM1_AQUAE (O67010)
FT   BINDING         36
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: R
FT   BINDING         66
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: R
FT   BINDING         84
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [DE]
FT   BINDING         113
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [ED]
FT   BINDING         114
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: A
FT   BINDING         247
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         250
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         266
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         269
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
XX
Size: 340-420;
Related: None;
Template: P81554; O67010;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Version: 21
# Last updated date: 2025-02-11
# Created date: 2005-02-28
//