AC   MF_00303;
DC   Protein; auto
TR   HAMAP; MF_00303; -; 1; level=0
XX
Names: Trigger_factor_Tig
XX
ID   TIG
DE   RecName: Full=Trigger factor;
DE            Short=TF;
DE            EC=5.2.1.8;
DE   AltName: Full=PPIase;
GN   Name=tig;
XX
CC   -!- FUNCTION: Involved in protein export. Acts as a chaperone by
CC       maintaining the newly synthesized protein in an open conformation.
CC       Functions as a peptidyl-prolyl cis-trans isomerase.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC         peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC         COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC         ChEBI:CHEBI:83834; EC=5.2.1.8;
case <OC:Escherichia> or <OC:Shigella>
CC   -!- SUBUNIT: Homodimer and monomer. In vivo most of the ribosomes are in
CC       complex with monomeric TF. Uncomplexed TF, however, is in a monomer-
CC       dimer equilibrium with approximately two thirds of TF existing in a
CC       dimeric state.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Note=About half TF is bound to the
CC       ribosome near the polypeptide exit tunnel while the other half is free
CC       in the cytoplasm.
CC   -!- DOMAIN: Consists of 3 domains; the N-terminus binds the ribosome, the
CC       middle domain has PPIase activity, while the C-terminus has intrinsic
CC       chaperone activity on its own.
CC   -!- SIMILARITY: Belongs to the FKBP-type PPIase family. Tig subfamily.
XX
DR   Pfam; PF00254; FKBP_C; 1; trigger=no
DR   Pfam; PF05698; Trigger_C; 1; trigger=no
DR   Pfam; PF05697; Trigger_N; 1; trigger=no
DR   PIRSF; PIRSF003095; Trigger_factor; 1; trigger=no
DR   NCBIfam; TIGR00115; Tig; 1; trigger=no
DR   PROSITE; PS50059; FKBP_PPIASE; 1; trigger=yes
XX
KW   Cell cycle
KW   Cell division
KW   Chaperone
KW   Cytoplasm
KW   Isomerase
KW   Rotamase
XX
GO   GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity
GO   GO:0006457; P:protein folding
GO   GO:0015031; P:protein transport
XX
FT   None
XX
Size: 404-557;
Related: None;
Template: P0A850;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Possible wrong start in AQUAE
XX
# Revision 1.27 2023/06/01
//