AC   MF_00316;
DC   Protein; auto
TR   HAMAP; MF_00316; -; 1; level=0
XX
Names: MobA
XX
ID   MOBA
case <OC:Pseudomonadota>
DE   RecName: Full=Molybdenum cofactor guanylyltransferase;
DE            Short=MoCo guanylyltransferase;
DE            EC=2.7.7.77;
DE   AltName: Full=GTP:molybdopterin guanylyltransferase;
DE   AltName: Full=Molybdopterin-guanine dinucleotide synthase;
DE            Short=MGD synthase;
DE   AltName: Full=Molybdopterin guanylyltransferase;
DE   AltName: Full=Mo-MPT guanylyltransferase;
else
DE   RecName: Full=Probable molybdenum cofactor guanylyltransferase;
DE            Short=MoCo guanylyltransferase;
DE            EC=2.7.7.77;
DE   AltName: Full=GTP:molybdopterin guanylyltransferase;
DE   AltName: Full=Molybdopterin-guanine dinucleotide synthase;
DE            Short=MGD synthase;
DE   AltName: Full=Molybdopterin guanylyltransferase;
DE   AltName: Full=Mo-MPT guanylyltransferase;
end case
GN   Name=mobA;
XX
CC   -!- FUNCTION: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT)
CC       cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine
CC       dinucleotide (Mo-MGD) cofactor.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin
CC         guanine dinucleotide; Xref=Rhea:RHEA:34243, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:71302,
CC         ChEBI:CHEBI:71310; EC=2.7.7.77;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
case <OC:Pseudomonadota>
CC   -!- SUBUNIT: Monomer.
end case
CC   -!- DOMAIN: The N-terminal domain determines nucleotide recognition and
CC       specific binding, while the C-terminal domain determines the specific
CC       binding to the target protein.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the MobA family.
XX
DR   NCBIfam; TIGR02665; Molyb_mobA; 1; trigger=no
XX
KW   Cytoplasm
KW   GTP-binding
KW   Magnesium
KW   Metal-binding
KW   Molybdenum cofactor biosynthesis
KW   Nucleotide-binding
KW   Transferase
XX
GO   GO:0005525; F:GTP binding
GO   GO:0070568; F:guanylyltransferase activity
GO   GO:0019720; P:Mo-molybdopterin cofactor metabolic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: MOBA_ECOLI (P32173)
FT   BINDING         12..14
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT   Condition: [LFIVT]-x-G
FT   BINDING         101
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: D
FT   BINDING         25
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT   Condition: [KR]
FT   BINDING         53
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT   Optional; Condition: [NRHK]
FT   BINDING         71
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT   Optional; Condition: D
FT   BINDING         101
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT   Condition: D
XX
Size: 189-225;
Related: None;
Template: P32173;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: MF_01224 (moaC)
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.35 2023/06/01
//