AC   MF_00322;
DC   Protein; auto
c?   <OC:Bacteria> or <OC:Archaea>
TR   HAMAP; MF_00322; -; 1; level=0
XX
Names: Top6B
XX
ID   TOP6B
DE   RecName: Full=Type 2 DNA topoisomerase 6 subunit B;
DE            EC=5.6.2.2;
DE   AltName: Full=Type II DNA topoisomerase VI subunit B;
DE            Short=TopoVI-B;
GN   Name=top6B;
XX
CC   -!- FUNCTION: Relaxes both positive and negative superturns and exhibits a
CC       strong decatenase activity.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2;
CC   -!- SUBUNIT: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
CC   -!- SIMILARITY: Belongs to the TOP6B family.
XX
DR   Pfam; PF02518; HATPase_c; 1; trigger=no
DR   Pfam; PF09239; Topo-VIb_trans; 1; trigger=no
DR   NCBIfam; TIGR01052; top6b; 1; trigger=no
DR   PIRSF; PIRSF006553; TopoVI_B; 1; trigger=no
XX
KW   ATP-binding
KW   DNA-binding
KW   Isomerase
KW   Nucleotide-binding
KW   Topoisomerase
XX
GO   GO:0005524; F:ATP binding
GO   GO:0003677; F:DNA binding
GO   GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO   GO:0006265; P:DNA topological change
GO   GO:0006268; P:DNA unwinding involved in DNA replication
XX
FT   From: TOP6B_SACSH (O05207)
FT   BINDING         97..98
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: [ST]-[KR]
FT   BINDING         106..113
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: G-x-x-G-[LIV]-G-x-[KSA]
FT   BINDING         42
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: N
FT   BINDING         76
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: D
FT   BINDING         427
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: K
XX
Size: 475-842;
Related: None;
Template: O05207; Q8PUB8;
Scope:
 Archaea
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.35 2023/06/01
//