AC   MF_00324;
DC   Protein; auto
TR   HAMAP; MF_00324; -; 1; level=0
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Names: DNApol_II_L_arch
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ID   DP2L
DE   RecName: Full=DNA polymerase II large subunit;
DE            Short=Pol II;
DE            EC=2.7.7.7;
DE   AltName: Full=Exodeoxyribonuclease large subunit;
DE            EC=3.1.11.1;
GN   Name=polC;
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CC   -!- FUNCTION: Possesses two activities: a DNA synthesis (polymerase) and an
CC       exonucleolytic activity that degrades single-stranded DNA in the 3'- to
CC       5'-direction. Has a template-primer preference which is characteristic
CC       of a replicative DNA polymerase.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC         nucleoside 5'-phosphates.; EC=3.1.11.1;
CC   -!- SUBUNIT: Heterodimer of a large subunit and a small subunit.
CC   -!- SIMILARITY: Belongs to the archaeal DNA polymerase II family.
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DR   Pfam; PF03833; PolC_DP2; 1; trigger=no
DR   NCBIfam; TIGR00354; PolC; 1; trigger=no
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KW   Transferase
KW   Nucleotidyltransferase
KW   DNA-directed DNA polymerase
KW   DNA replication
KW   Hydrolase
KW   Nuclease
KW   Exonuclease
KW   DNA-binding
KW   Multifunctional enzyme
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GO   GO:0008408; F:3'-5' exonuclease activity
GO   GO:0003677; F:DNA binding
GO   GO:0003887; F:DNA-directed DNA polymerase activity
GO   GO:0006308; P:DNA catabolic process
GO   GO:0006261; P:DNA-templated DNA replication
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FT   None
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Size: 1080-1270;
Related: None;
Template: Q59024; P81409;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Inteins deleted in HALMA, HALWD, HALSA, METMJ, METHJ, PYRAB, PYRHO and THEKO.
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# Revision 1.31 2023/06/01
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