AC   MF_00334;
DC   Protein; auto
TR   HAMAP; MF_00334; -; 1; level=0
XX
Names: Homogentis_dioxygen
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ID   HGD
DE   RecName: Full=Homogentisate 1,2-dioxygenase;
DE            Short=HGDO;
DE            EC=1.13.11.5;
DE   AltName: Full=Homogentisate oxygenase;
DE   AltName: Full=Homogentisic acid oxidase;
DE   AltName: Full=Homogentisicase;
GN   Name=hmgA;
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CC   -!- FUNCTION: Involved in the catabolism of homogentisate (2,5-
CC       dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the
CC       degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring
CC       cleavage of the aromatic ring of homogentisate to yield
CC       maleylacetoacetate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=homogentisate + O2 = 4-maleylacetoacetate + H(+);
CC         Xref=Rhea:RHEA:15449, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:16169, ChEBI:CHEBI:17105; EC=1.13.11.5;
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetate and fumarate from L-phenylalanine: step 4/6.
CC   -!- SUBUNIT: Hexamer; dimer of trimers.
CC   -!- SIMILARITY: Belongs to the homogentisate dioxygenase family.
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DR   Pfam; PF04209; HgmA; 1; trigger=no
DR   NCBIfam; TIGR01015; HmgA; 1; trigger=no
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KW   Oxidoreductase
KW   Dioxygenase
KW   Metal-binding
KW   Iron
KW   Phenylalanine catabolism
KW   Tyrosine catabolism
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GO   GO:0004411; F:homogentisate 1,2-dioxygenase activity
GO   GO:0005506; F:iron ion binding
GO   GO:0006559; P:L-phenylalanine catabolic process
GO   GO:0006572; P:tyrosine catabolic process
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FT   From: HGD_PSEPK (Q88E47)
FT   ACT_SITE        288
FT                   /note="Proton acceptor"
FT   Condition: H
FT   BINDING         349
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   Condition: H
FT   BINDING         355
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   Condition: E
FT   BINDING         385
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   Condition: H
FT   BINDING         346
FT                   /ligand="homogentisate"
FT                   /ligand_id="ChEBI:CHEBI:16169"
FT   Condition: y
FT   BINDING         367
FT                   /ligand="homogentisate"
FT                   /ligand_id="ChEBI:CHEBI:16169"
FT   Condition: H
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Size: 416-458;
Related: None;
Template: Q88E47; Q6EMI9;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: in RALN1
Comments: None
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# Revision 1.33 2023/11/28
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