AC   MF_00347;
DC   Protein; auto
TR   HAMAP; MF_00347; -; 1; level=0
XX
Names: Polyphosphate_kinase
XX
ID   PPK1
DE   RecName: Full=Polyphosphate kinase;
DE            EC=2.7.4.1;
DE   AltName: Full=ATP-polyphosphate phosphotransferase;
DE   AltName: Full=Polyphosphoric acid kinase;
GN   Name=ppk;
XX
CC   -!- FUNCTION: Catalyzes the reversible transfer of the terminal phosphate
CC       of ATP to form a long-chain polyphosphate (polyP).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[phosphate](n) + ATP = [phosphate](n+1) + ADP;
CC         Xref=Rhea:RHEA:19573, Rhea:RHEA-COMP:9859, Rhea:RHEA-COMP:14280,
CC         ChEBI:CHEBI:16838, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; EC=2.7.4.1;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
end case
CC   -!- PTM: An intermediate of this reaction is the autophosphorylated ppk in
CC       which a phosphate is covalently linked to a histidine residue through a
CC       N-P bond.
CC   -!- SIMILARITY: Belongs to the polyphosphate kinase 1 (PPK1) family.
XX
DR   Pfam; PF02503; PP_kinase; 1; trigger=no
DR   Pfam; PF13090; PP_kinase_C; 1; trigger=no
DR   Pfam; PF13089; PP_kinase_N; 1; trigger=no
DR   PIRSF; PIRSF015589; PP_kinase; 1; trigger=no
DR   NCBIfam; TIGR03705; poly_P_kin; 1; trigger=no
DR   PROSITE; PS50035; PLD; 0-1; trigger=yes
XX
KW   ATP-binding
KW   Kinase
case <FTGroup:1>
KW   Magnesium
KW   Metal-binding
end case
KW   Nucleotide-binding
KW   Phosphoprotein
KW   Transferase
XX
GO   GO:0008976; F:polyphosphate kinase activity
GO   GO:0006799; P:polyphosphate biosynthetic process
XX
FT   From: PPK1_ECOLI (P0A7B1)
FT   ACT_SITE        435
FT                   /note="Phosphohistidine intermediate"
FT   Condition: H
FT   BINDING         375
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Group: 1; Condition: R
FT   BINDING         405
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Group: 1; Condition: R
FT   BINDING         45
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: N
FT   BINDING         468
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: Y
FT   BINDING         564
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: R
FT   BINDING         592
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: H
XX
Size: 640-850;
Related: None;
Template: P0A7B1; Q07411; Q9JXS9;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.33 2023/06/01
//