AC MF_00351; DC Protein; auto TR HAMAP; MF_00351; -; 1; level=0 XX Names: RNA_methyltransf_FlpA XX ID FLPA DE RecName: Full=Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase; DE EC=2.1.1.-; GN Name=flpA; XX CC -!- FUNCTION: Involved in pre-rRNA and tRNA processing. Utilizes the methyl CC donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl CC methylation of ribose moieties in rRNA and tRNA. Site specificity is CC provided by a guide RNA that base pairs with the substrate. Methylation CC occurs at a characteristic distance from the sequence involved in base CC pairing with the guide RNA. CC -!- SUBUNIT: Interacts with nop5. Component of box C/D small CC ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, CC plus a guide RNA. CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. Fibrillarin CC family. XX DR Pfam; PF01269; Fibrillarin; 1; trigger=no DR PRINTS; PR00052; FIBRILLARIN; 1; trigger=no DR PROSITE; PS00566; FIBRILLARIN; 1; trigger=no XX KW Methyltransferase KW RNA-binding KW rRNA processing KW Transferase KW tRNA processing XX GO GO:0003723; F:RNA binding GO GO:0008168; F:methyltransferase activity GO GO:0006364; P:rRNA processing GO GO:0008033; P:tRNA processing XX FT From: FLPA_AERPE (Q9Y9U3) FT BINDING 90..91 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: [TS]-T FT BINDING 109..110 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: [ED]-x FT BINDING 134..135 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: [DN]-[AS] FT BINDING 154..157 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: D-[IVL]-[SA]-[QT] XX Size: 185-245; Related: None; Template: O28192; P58032; Q58108; Q8U4M2; Q9Y9U3; Scope: Archaea Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: The "x" in the condition of the second S-adenosyl-L-methionine-binding region most often is a large and hydrophobic residue (pi-stacking interaction). XX # Revision 1.20 2022/11/19 //