AC   MF_00361;
DC   Protein; auto
TR   HAMAP; MF_00361; -; 1; level=0
XX
Names: NAD_kinase
XX
ID   NADK
DE   RecName: Full=NAD kinase;
DE            EC=2.7.1.23;
DE   AltName: Full=ATP-dependent NAD kinase;
GN   Name=nadK;
XX
CC   -!- FUNCTION: Involved in the regulation of the intracellular balance of
CC       NAD and NADP, and is a key enzyme in the biosynthesis of NADP.
CC       Catalyzes specifically the phosphorylation on 2'-hydroxyl of the
CC       adenosine moiety of NAD to yield NADP.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + NAD(+) = ADP + H(+) + NADP(+); Xref=Rhea:RHEA:18629,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:456216; EC=2.7.1.23;
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the NAD kinase family.
XX
DR   Pfam; PF01513; NAD_kinase; 1; trigger=no
XX
KW   ATP-binding
KW   Cytoplasm
KW   Kinase
KW   NAD
KW   NADP
KW   Nucleotide-binding
KW   Transferase
XX
GO   GO:0003951; F:NAD+ kinase activity
GO   GO:0046872; F:metal ion binding
GO   GO:0005737; C:cytoplasm
GO   GO:0006741; P:NADP biosynthetic process
XX
FT   From: NADK_ARCFU (O30297)
FT   BINDING         49..50
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: [DN]-[GA]
FT   BINDING         115..116
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: [NDE]-[ED]
FT   BINDING         156..161
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: [TS]-x-[YHW]-x-x-S
FT   ACT_SITE        49
FT                   /note="Proton acceptor"
FT   Condition: [DN]
FT   BINDING         54
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: [RKH]
FT   BINDING         126
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: [KHR]
FT   BINDING         143
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: [RKH]
FT   BINDING         145
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: [DN]
FT   BINDING         153
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: [ILVA]
FT   BINDING         180
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: [ALV]
FT   BINDING         211
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: [QN]
XX
Size: 248-363;
Related: None;
Template: O30297; Q8Y8D7; P9WHV7; P0A7B3; O58801; O31612; P65774; Q58327;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: <Inositol_P>
 Cter: None
Duplicate: in NOSS1, HALH5, BACSU, LISIN, LISMO, SYNY3
Plasmid: None
Comments: None
XX
# Revision 1.32 2023/01/17
//