AC   MF_00367;
DC   Protein; auto
TR   HAMAP; MF_00367; -; 1; level=0
XX
Names: GTPase_Era
XX
ID   ERA
DE   RecName: Full=GTPase Era;
GN   Name=era;
XX
case not <OC:Mycobacteriaceae>
CC   -!- FUNCTION: An essential GTPase that binds both GDP and GTP, with rapid
CC       nucleotide exchange. Plays a role in 16S rRNA processing and 30S
CC       ribosomal subunit biogenesis and possibly also in cell cycle regulation
CC       and energy metabolism.
else case <OC:Mycobacteriaceae>
CC   -!- FUNCTION: Exhibits GTPase activity. Binds RNA but is probably not
CC       involved in ribosome assembly in mycobacteria.
end case
CC   -!- SUBUNIT: Monomer.
case <OC:Mycobacteriaceae>
CC   -!- SUBCELLULAR LOCATION: Cell envelope. Secreted, cell wall.
else case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane
CC       protein.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Cell inner membrane; Peripheral
CC       membrane protein.
end case
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. Era GTPase family.
XX
DR   Pfam; PF07650; KH_2; 1; trigger=no
DR   Pfam; PF01926; MMR_HSR1; 1; trigger=no
DR   PRINTS; PR00326; GTP1OBG; 1; trigger=no
DR   NCBIfam; TIGR00436; Era; 1; trigger=no
DR   NCBIfam; TIGR00231; Small_GTP; 1; trigger=no
DR   PROSITE; PS50823; KH_TYPE_2; 1; trigger=yes
DR   PROSITE; PS51713; G_ERA; 1; trigger=yes
XX
KW   GTP-binding
KW   Nucleotide-binding
KW   RNA-binding
case not <OC:Mycobacteriaceae>
KW   Cell membrane
KW   Cytoplasm
KW   Membrane
KW   Ribosome biogenesis
KW   rRNA-binding
end case
case (defined <Property:Membrane> and <Property:Membrane=2>) and not <OC:Mycobacteriaceae>
KW   Cell inner membrane
end case
case <OC:Mycobacteriaceae>
KW   Cell wall
KW   Secreted
end case
XX
GO   GO:0005525; F:GTP binding
GO   GO:0003924; F:GTPase activity
case not <OC:Mycobacteriaceae>
GO   GO:0070181; F:small ribosomal subunit rRNA binding
GO   GO:0042274; P:ribosomal small subunit biogenesis
GO   GO:0005737; C:cytoplasm
GO   GO:0005886; C:plasma membrane
end case
XX
FT   From: ERA_ECOLI (P06616)
FT   BINDING         15..22
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT   Condition: G-x-[PTA]-x-x-G-K-S
FT   BINDING         62..66
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT   Condition: D-[TV]-P-G-x
FT   BINDING         124..127
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT   Condition: x-K-x-x
XX
Size: 278-325;
Related: None;
Template: P06616; O67800; P37214; P42182; P0A3C4; Q5SM23; A5U557; A0R0S7;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: RICCN has an RPE1 insert in its N-terminus and so is considered
 atypical.
XX
# Revision 1.41 2023/06/01
//