AC   MF_00376;
DC   Protein; auto
TR   HAMAP; MF_00376; -; 1; level=0
XX
Names: Dephospho_CoA_kinase
XX
ID   COAE
DE   RecName: Full=Dephospho-CoA kinase;
DE            EC=2.7.1.24;
DE   AltName: Full=Dephosphocoenzyme A kinase;
GN   Name=coaE;
XX
CC   -!- FUNCTION: Catalyzes the phosphorylation of the 3'-hydroxyl group of
CC       dephosphocoenzyme A to form coenzyme A.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3'-dephospho-CoA + ATP = ADP + CoA + H(+);
CC         Xref=Rhea:RHEA:18245, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:456216;
CC         EC=2.7.1.24;
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-
CC       pantothenate: step 5/5.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
case <Feature:PF04229>
CC   -!- DOMAIN: The C-terminal UPF0157 domain is involved in the proper folding
CC       of the full length enzyme.
end case
CC   -!- SIMILARITY: Belongs to the CoaE family.
XX
DR   Pfam; PF01121; CoaE; 1; trigger=no
DR   Pfam; PF04229; GrpB; 0-1; trigger=no
DR   NCBIfam; TIGR00152; TIGR00152; 1; trigger=no
DR   PROSITE; PS51219; DPCK; 1; trigger=yes
XX
KW   Cytoplasm
KW   Transferase
KW   Kinase
KW   ATP-binding
KW   Nucleotide-binding
KW   Coenzyme A biosynthesis
XX
GO   GO:0005524; F:ATP binding
GO   GO:0004140; F:dephospho-CoA kinase activity
GO   GO:0015937; P:coenzyme A biosynthetic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: COAE_ECOLI (P0A6I9)
FT   BINDING         12..17
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [GASC]-x-G-K-[STDN]-x
XX
Size: 150-300;
Related: None;
Template: P0A6I9; P9WPA3; Q56416;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: <UPF0157>
Duplicate: None
Plasmid: None
Comments: The UPF0157 (GrpB) C-terminal domain present in some species is probably involved
 in the folding of the protein.
 Natural frameshift reported in NEIMB.
XX
# Revision 1.39 2023/06/01
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