AC   MF_00377;
DC   Protein; auto
TR   HAMAP; MF_00377; -; 1; level=0
XX
Names: DnaA_bact
XX
ID   DNAA
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA;
XX
CC   -!- FUNCTION: Plays an essential role in the initiation and regulation of
CC       chromosomal replication. ATP-DnaA binds to the origin of replication
CC       (oriC) to initiate formation of the DNA replication initiation complex
CC       once per cell cycle. Binds the DnaA box (a 9 base pair repeat at the
CC       origin) and separates the double-stranded (ds)DNA. Forms a right-handed
CC       helical filament on oriC DNA; dsDNA binds to the exterior of the
CC       filament while single-stranded (ss)DNA is stabiized in the filament's
CC       interior. The ATP-DnaA-oriC complex binds and stabilizes one strand of
CC       the AT-rich DNA unwinding element (DUE), permitting loading of DNA
CC       polymerase. After initiation quickly degrades to an ADP-DnaA complex
CC       that is not apt for DNA replication. Binds acidic phospholipids.
CC   -!- SUBUNIT: Oligomerizes as a right-handed, spiral filament on DNA at
CC       oriC.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- DOMAIN: Domain I is involved in oligomerization and binding regulators,
CC       domain II is flexibile and of varying length in different bacteria,
CC       domain III forms the AAA+ region, while domain IV binds dsDNA.
CC   -!- SIMILARITY: Belongs to the DnaA family.
XX
DR   Pfam; PF00308; Bac_DnaA; 1; trigger=no
DR   Pfam; PF08299; Bac_DnaA_C; 1; trigger=no
DR   PRINTS; PR00051; DNAA; 1; trigger=no
DR   NCBIfam; TIGR00362; DnaA; 1; trigger=no
DR   PROSITE; PS01008; DNAA; 1; trigger=no
XX
KW   Cytoplasm
KW   DNA replication
KW   DNA-binding
KW   ATP-binding
KW   Nucleotide-binding
KW   Lipid-binding
XX
GO   GO:0005524; F:ATP binding
GO   GO:0003688; F:DNA replication origin binding
GO   GO:0006270; P:DNA replication initiation
GO   GO:0006275; P:regulation of DNA replication
GO   GO:0005737; C:cytoplasm
XX
FT   From: DNAA_ECOLI (P03004)
FT   REGION          Nter..90
FT                   /note="Domain I, interacts with DnaA modulators"
FT   REGION          91..130
FT                   /note="Domain II"
FT   REGION          131..347
FT                   /note="Domain III, AAA+ region"
FT   REGION          348..Cter
FT                   /note="Domain IV, binds dsDNA"
FT   From: DNAA_AQUAE (O66659)
FT   BINDING         122
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [GSA]
FT   BINDING         124
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [GS]
FT   BINDING         125
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: K
FT   BINDING         126
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [ST]
XX
Size: 399-656;
Related: None;
Template: P03004; P05648; O66659;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in CHLMU, CHLPN, CHLTR
Plasmid: None
Comments: None
XX
# Version: 22
# Last updated date: 2024-11-08
# Created date: 2005-02-28
//