AC   MF_00384;
DC   Protein; auto
TR   HAMAP; MF_00384; -; 1; level=0
XX
Names: Homoser_kinase
XX
ID   KHSE
DE   RecName: Full=Homoserine kinase;
DE            Short=HK;
DE            Short=HSK;
DE            EC=2.7.1.39;
GN   Name=thrB;
XX
CC   -!- FUNCTION: Catalyzes the ATP-dependent phosphorylation of L-homoserine
CC       to L-homoserine phosphate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine;
CC         Xref=Rhea:RHEA:13985, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57590, ChEBI:CHEBI:456216;
CC         EC=2.7.1.39;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine
CC       from L-aspartate: step 4/5.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. Homoserine kinase
CC       subfamily.
XX
DR   Pfam; PF08544; GHMP_kinases_C; 1; trigger=no
DR   Pfam; PF00288; GHMP_kinases_N; 1; trigger=no
DR   PIRSF; PIRSF000676; Homoser_kin; 1; trigger=no
DR   PRINTS; PR00958; HOMSERKINASE; 1; trigger=no
DR   NCBIfam; TIGR00191; ThrB; 1; trigger=no
DR   PROSITE; PS00627; GHMP_KINASES_ATP; 1; trigger=no
XX
KW   Cytoplasm
KW   Amino-acid biosynthesis
KW   Threonine biosynthesis
KW   Transferase
KW   Kinase
KW   ATP-binding
KW   Nucleotide-binding
XX
GO   GO:0005524; F:ATP binding
GO   GO:0004413; F:homoserine kinase activity
GO   GO:0009088; P:threonine biosynthetic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: KHSE_ECOLI (P00547)
FT   BINDING         91..101
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [APKR]-x(3)-G-[LFM]-G-[GS]-S-[GSA]-[STAC]
XX
Size: 281-324;
Related: MF_00217;
Template: P00547; Q6M0H5; Q58504;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Some other species have a non-classical-type thrB
XX
# Revision 1.33 2023/06/01
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