AC   MF_00388;
DC   Protein; auto
TR   HAMAP; MF_00388; -; 1; level=0
XX
Names: LpxC
XX
ID   LPXC
DE   RecName: Full=UDP-3-O-acyl-N-acetylglucosamine deacetylase;
DE            Short=UDP-3-O-acyl-GlcNAc deacetylase;
DE            EC=3.5.1.108;
DE   AltName: Full=UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase;
GN   Name=lpxC;
XX
case <OC:Bacteria>
CC   -!- FUNCTION: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-
CC       acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the
CC       committed step in lipid A biosynthesis.
end case
case <OG:Chloroplast>
CC   -!- FUNCTION: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-
CC       acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate.
CC       Involved in the biosynthesis of lipid A, a phosphorylated glycolipid
CC       that in bacteria anchors the lipopolysaccharide to the outer membrane
CC       of the cell. The target for the lipopolysaccharides produced in the
CC       chloroplast could either be the cell envelope of the eukaryote or the
CC       plastid membrane.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine +
CC         H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate;
CC         Xref=Rhea:RHEA:67816, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:137740, ChEBI:CHEBI:173225; EC=3.5.1.108;
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC   -!- PATHWAY: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A)
CC       from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-
CC       acetyl-alpha-D-glucosamine: step 2/6.
case <OG:Chloroplast>
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast.
end case
CC   -!- SIMILARITY: Belongs to the LpxC family.
XX
DR   Pfam; PF03331; LpxC; 1; trigger=no
DR   NCBIfam; TIGR00325; lpxC; 1; trigger=no
XX
KW   Hydrolase
KW   Lipid A biosynthesis
KW   Lipid biosynthesis
KW   Lipid metabolism
KW   Metal-binding
KW   Zinc
XX
GO   GO:0008759; F:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GO   GO:0009245; P:lipid A biosynthetic process
case <OG:Chloroplast>
GO   GO:0009507; C:chloroplast
end case
XX
FT   From: LPXC_ECOLI (P0A725)
FT   ACT_SITE        265
FT                   /note="Proton donor"
FT   Condition: H
FT   BINDING         79
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: H
FT   BINDING         238
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: H
FT   BINDING         242
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: D
XX
Size: 250-350;
Related: None;
Template: P0A725; O67648; P47205;
Scope:
 Bacteria
 Plastid
Fusion:
 Nter: None
 Cter: MF_00406 (fabZ)
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.32 2023/06/01
//