AC   MF_00392;
DC   Protein; auto
TR   HAMAP; MF_00392; -; 1; level=0
XX
Names: LpxB
XX
ID   LPXB
DE   RecName: Full=Lipid-A-disaccharide synthase;
DE            EC=2.4.1.182;
GN   Name=lpxB;
XX
CC   -!- FUNCTION: Condensation of UDP-2,3-diacylglucosamine and 2,3-
CC       diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor
CC       of lipid A, a phosphorylated glycolipid that anchors the
CC       lipopolysaccharide to the outer membrane of the cell.
case <OC:Enterobacterales>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl
CC         1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-
CC         glucosamine = H(+) + lipid A disaccharide (E. coli) + UDP;
CC         Xref=Rhea:RHEA:22668, ChEBI:CHEBI:15378, ChEBI:CHEBI:57957,
CC         ChEBI:CHEBI:58223, ChEBI:CHEBI:58466, ChEBI:CHEBI:78847;
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-
CC         glucosamine = a lipid A disaccharide + H(+) + UDP;
CC         Xref=Rhea:RHEA:67828, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:137748, ChEBI:CHEBI:176338, ChEBI:CHEBI:176343;
CC         EC=2.4.1.182;
case <OC:Enterobacterales>
CC   -!- PATHWAY: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A)
CC       from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-
CC       acetyl-alpha-D-glucosamine: step 5/6.
else
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.
end case
CC   -!- SIMILARITY: Belongs to the LpxB family.
XX
DR   Pfam; PF02684; LpxB; 1; trigger=no
DR   NCBIfam; TIGR00215; LpxB; 1; trigger=no
XX
KW   Glycosyltransferase
KW   Lipid A biosynthesis
KW   Lipid biosynthesis
KW   Lipid metabolism
KW   Transferase
XX
GO   GO:0008915; F:lipid-A-disaccharide synthase activity
GO   GO:0009245; P:lipid A biosynthetic process
XX
FT   None
XX
Size: 356-439;
Related: None;
Template: P10441;
Scope:
 Bacteria
Fusion:
 Nter: <Unknown>
 Cter: None
Duplicate: None
Plasmid: None
Comments: Unknown N-terminal domain in Chlamydiaceae.
 Possible wrong start in XANAC.
XX
# Revision 1.28 2023/06/01
//