AC MF_00399; DC Protein; auto TR HAMAP; MF_00399; -; 1; level=0 XX Names: DbsD XX ID DSBD DE RecName: Full=Thiol:disulfide interchange protein DsbD; DE EC=1.8.1.8; DE AltName: Full=Protein-disulfide reductase; DE Short=Disulfide reductase; case DE + Flags: Precursor; end case GN Name=dsbD; XX CC -!- FUNCTION: Required to facilitate the formation of correct disulfide CC bonds in some periplasmic proteins and for the assembly of the CC periplasmic c-type cytochromes. Acts by transferring electrons from CC cytoplasmic thioredoxin to the periplasm. This transfer involves a CC cascade of disulfide bond formation and reduction steps. CC -!- CATALYTIC ACTIVITY: CC Reaction=[protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) + CC NADH; Xref=Rhea:RHEA:18749, Rhea:RHEA-COMP:10593, Rhea:RHEA- CC COMP:10594, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.8.1.8; CC -!- CATALYTIC ACTIVITY: CC Reaction=[protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) + CC NADPH; Xref=Rhea:RHEA:18753, Rhea:RHEA-COMP:10593, Rhea:RHEA- CC COMP:10594, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.8; CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the thioredoxin family. DsbD subfamily. XX DR Pfam; PF02683; DsbD; 1; trigger=no DR Pfam; PF00085; Thioredoxin; 1; trigger=no DR PRINTS; PR00421; THIOREDOXIN; 1; trigger=no DR PROSITE; PS00194; THIOREDOXIN_1; 1; trigger=no DR PROSITE; PS51352; THIOREDOXIN_2; 1; trigger=yes DR General; Signal; -; 1; trigger=yes DR General; Transmembrane; -; 7-9; trigger=yes XX KW Cell inner membrane KW Cell membrane KW Cytochrome c-type biogenesis KW Disulfide bond KW Electron transport KW Membrane KW NAD KW Oxidoreductase KW Redox-active center case KW Signal end case KW Transmembrane KW Transport KW Transmembrane helix XX GO GO:0009055; F:electron transfer activity GO GO:0047134; F:protein-disulfide reductase (NAD(P)) activity GO GO:0017004; P:cytochrome complex assembly GO GO:0005886; C:plasma membrane XX FT From: DSBD_ECOLI (P36655) FT DISULFID 122..128 FT /note="Redox-active" FT Condition: C-x(4,5)-C FT DISULFID 182..304 FT /note="Redox-active" FT Condition: C-x*-C FT DISULFID 480..483 FT /note="Redox-active" FT Condition: C-x(2)-C XX Size: 565-608; Related: None; Template: P36655; Scope: Bacteria Fusion: Nter: None Cter: None Duplicate: in PSEAE Plasmid: None Comments: Possible wrong start in RALSO XX # Revision 1.43 2022/01/28 //