AC   MF_00409;
DC   Protein; auto
TR   HAMAP; MF_00409; -; 1; level=0
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Names: LpxK
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ID   LPXK
DE   RecName: Full=Tetraacyldisaccharide 4'-kinase;
DE            EC=2.7.1.130;
DE   AltName: Full=Lipid A 4'-kinase;
GN   Name=lpxK;
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CC   -!- FUNCTION: Transfers the gamma-phosphate of ATP to the 4'-position of a
CC       tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form
CC       tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a lipid A disaccharide + ATP = a lipid IVA + ADP + H(+);
CC         Xref=Rhea:RHEA:67840, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:176343, ChEBI:CHEBI:176425, ChEBI:CHEBI:456216;
CC         EC=2.7.1.130;
CC   -!- PATHWAY: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A)
CC       from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-
CC       acetyl-alpha-D-glucosamine: step 6/6.
CC   -!- SIMILARITY: Belongs to the LpxK family.
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DR   Pfam; PF02606; LpxK; 1; trigger=no
DR   NCBIfam; TIGR00682; LpxK; 1; trigger=no
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KW   ATP-binding
KW   Kinase
KW   Lipid A biosynthesis
KW   Lipid biosynthesis
KW   Lipid metabolism
KW   Nucleotide-binding
KW   Transferase
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GO   GO:0005524; F:ATP binding
GO   GO:0009029; F:tetraacyldisaccharide 4'-kinase activity
GO   GO:0009245; P:lipid A biosynthetic process
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FT   From: LPXK_ECOLI (P27300)
FT   BINDING         55..62
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: x(2)-G-G-x-G-K-T
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Size: 305-385;
Related: None;
Template: P27300;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: MF_01187 (Ynnn)
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.32 2023/06/01
//