AC   MF_00413;
DC   Protein; auto
TR   HAMAP; MF_00413; -; 1; level=0
XX
Names: Thiourid_synth_A
XX
ID   TUSA
case <OC:Enterobacterales>
DE   RecName: Full=Sulfur carrier protein TusA;
DE   AltName: Full=Sulfur mediator TusA;
DE   AltName: Full=Sulfur transfer protein TusA;
DE   AltName: Full=tRNA 2-thiouridine synthesizing protein A;
else
DE   RecName: Full=Sulfur carrier protein TusA;
end case
GN   Name=tusA;
XX
case <OC:Enterobacterales>
CC   -!- FUNCTION: Sulfur carrier protein involved in sulfur trafficking in the
CC       cell. Part of a sulfur-relay system required for 2-thiolation during
CC       synthesis of 2-thiouridine of the modified wobble base 5-
CC       methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with
CC       IscS and stimulates its cysteine desulfurase activity. Accepts an
CC       activated sulfur from IscS, which is then transferred to TusD, and thus
CC       determines the direction of sulfur flow from IscS to 2-thiouridine
CC       formation. Also appears to be involved in sulfur transfer for the
CC       biosynthesis of molybdopterin.
CC   -!- SUBUNIT: Interacts with IscS.
CC   -!- PATHWAY: tRNA modification.
else
CC   -!- FUNCTION: Sulfur carrier protein which probably makes part of a sulfur-
CC       relay system.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the sulfur carrier protein TusA family.
XX
DR   PROSITE; PS01148; UPF0033; 1; trigger=no
DR   Pfam; PF01206; TusA; 1; trigger=no
XX
KW   Cytoplasm
case <OC:Enterobacterales>
KW   tRNA processing
end case
XX
GO   GO:0097163; F:sulfur carrier activity
case <OC:Enterobacterales>
GO   GO:0006400; P:tRNA modification
end case
GO   GO:0005737; C:cytoplasm
XX
FT   From: TUSA_ECOLI (P0A890)
FT   ACT_SITE        19
FT                   /note="Cysteine persulfide intermediate"
FT   Condition: C
XX
Size: 76-84;
Related: None;
Template: P0A890;
Scope:
 Bacteria; Gammaproteobacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.24 2024/01/31
//