AC   MF_00423;
DC   Protein; auto
TR   HAMAP; MF_00423; -; 1; level=0
XX
Names: SelA
XX
ID   SELA
DE   RecName: Full=L-seryl-tRNA(Sec) selenium transferase;
DE            EC=2.9.1.1;
DE   AltName: Full=Selenocysteine synthase;
DE            Short=Sec synthase;
DE   AltName: Full=Selenocysteinyl-tRNA(Sec) synthase;
GN   Name=selA;
XX
CC   -!- FUNCTION: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec)
CC       required for selenoprotein biosynthesis.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + L-seryl-tRNA(Sec) + selenophosphate = L-
CC         selenocysteinyl-tRNA(Sec) + phosphate; Xref=Rhea:RHEA:22728,
CC         Rhea:RHEA-COMP:9742, Rhea:RHEA-COMP:9743, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16144, ChEBI:CHEBI:43474, ChEBI:CHEBI:78533,
CC         ChEBI:CHEBI:78573; EC=2.9.1.1;
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC   -!- PATHWAY: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec)
CC       biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec)
CC       (bacterial route): step 1/1.
case <OC:Enterobacterales>
CC   -!- SUBUNIT: Homodecamer; pentamer of dimers. Binds only one seryl-
CC       tRNA(Sec) per dimer.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the SelA family.
XX
DR   Pfam; PF03841; SelA; 1; trigger=no
DR   NCBIfam; TIGR00474; SelA; 1; trigger=no
XX
KW   Cytoplasm
KW   Transferase
KW   Pyridoxal phosphate
KW   Selenium
KW   Protein biosynthesis
XX
GO   GO:0004125; F:L-seryl-tRNA(Sec) selenium transferase activity
GO   GO:0001514; P:selenocysteine incorporation
GO   GO:0005737; C:cytoplasm
XX
FT   From: SELA_ECOLI (P0A821)
FT   MOD_RES         295
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT   Condition: K
XX
Size: 386-475;
Related: None;
Template: P0A821; P56372; O33277;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: in RHIME
Comments: A divergent RHILO gene exists (mlr3804)
XX
# Revision 1.31 2023/07/27
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