AC   MF_00427;
DC   Protein; auto
TR   HAMAP; MF_00427; -; 1; level=0
XX
Names: NqrC
XX
ID   NQRC
DE   RecName: Full=Na(+)-translocating NADH-quinone reductase subunit C;
DE            Short=Na(+)-NQR subunit C;
DE            Short=Na(+)-translocating NQR subunit C;
DE            EC=7.2.1.1;
DE   AltName: Full=NQR complex subunit C;
DE   AltName: Full=NQR-1 subunit C;
GN   Name=nqrC;
XX
CC   -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC       ubiquinol by two successive reactions, coupled with the transport of
CC       Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC       probably involved in the second step, the conversion of ubisemiquinone
CC       to ubiquinol.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC         Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC         Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=7.2.1.1;
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC   -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC       NqrF.
case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane
CC       protein.
end case
case <FT:1>
CC   -!- CAUTION: The residue potentially involved in the covalent binding of
CC       FMN is a Ser instead of a Thr.
end case
CC   -!- SIMILARITY: Belongs to the NqrC family.
XX
DR   Pfam; PF04205; FMN_bind; 1; trigger=no
DR   PIRSF; PIRSF009437; NQR-1_subunit_C; 1; trigger=no
DR   NCBIfam; TIGR01938; NqrC; 1; trigger=no
DR   General; Transmembrane; -; 1; trigger=yes
XX
KW   Translocase
KW   NAD
KW   Ubiquinone
KW   Transport
KW   Ion transport
KW   Sodium
KW   Sodium transport
KW   Flavoprotein
KW   FMN
KW   Membrane
KW   Transmembrane
KW   Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
case <FT:1> or <FT:2>
KW   Phosphoprotein
end case
KW   Transmembrane helix
XX
GO   GO:0010181; F:FMN binding
GO   GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO   GO:0006814; P:sodium ion transport
GO   GO:0005886; C:plasma membrane
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FT   From: NQRC_VIBAL (Q56582)
FT   MOD_RES         224
FT                   /note="FMN phosphoryl serine"
FT   Optional; Condition: S
FT   MOD_RES         224
FT                   /note="FMN phosphoryl threonine"
FT   Optional; Condition: T
XX
Size: 220-320;
Related: None;
Template: Q56582; A5F5Y7;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.42 2023/06/01
//