AC   MF_00430;
DC   Protein; auto
TR   HAMAP; MF_00430; -; 1; level=0
XX
Names: NqrF
XX
ID   NQRF
DE   RecName: Full=Na(+)-translocating NADH-quinone reductase subunit F;
DE            Short=Na(+)-NQR subunit F;
DE            Short=Na(+)-translocating NQR subunit F;
DE            EC=7.2.1.1;
DE   AltName: Full=NQR complex subunit F;
DE   AltName: Full=NQR-1 subunit F;
GN   Name=nqrF;
XX
CC   -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC       ubiquinol by two successive reactions, coupled with the transport of
CC       Na(+) ions from the cytoplasm to the periplasm. The first step is
CC       catalyzed by NqrF, which accepts electrons from NADH and reduces
CC       ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC         Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC         Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=7.2.1.1;
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC       Note=Binds 1 [2Fe-2S] cluster.;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC   -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC       NqrF.
case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane
CC       protein.
end case
CC   -!- SIMILARITY: Belongs to the NqrF family.
XX
DR   Pfam; PF00970; FAD_binding_6; 1; trigger=no
DR   Pfam; PF00111; Fer2; 1; trigger=no
DR   Pfam; PF00175; NAD_binding_1; 1; trigger=no
DR   PRINTS; PR00371; FPNCR; 1; trigger=no
DR   NCBIfam; TIGR01941; NqrF; 1; trigger=no
DR   PROSITE; PS00197; 2FE2S_FER_1; 1; trigger=no
DR   PROSITE; PS51085; 2FE2S_FER_2; 1; trigger=yes
DR   PROSITE; PS51384; FAD_FR; 1; trigger=yes
DR   General; Transmembrane; -; 1; trigger=yes
XX
KW   Translocase
KW   NAD
KW   Ubiquinone
KW   Transport
KW   Ion transport
KW   Sodium
KW   Sodium transport
KW   Flavoprotein
KW   FAD
case <Feature:PS51085>
KW   Metal-binding
KW   Iron-sulfur
KW   Iron
KW   2Fe-2S
end case
KW   Membrane
KW   Transmembrane
KW   Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
KW   Transmembrane helix
XX
GO   GO:0009055; F:electron transfer activity
GO   GO:0006814; P:sodium ion transport
GO   GO:0005886; C:plasma membrane
XX
FT   From: NQRF_VIBAL (Q56584)
FT   BINDING         69
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT   Condition: C
FT   BINDING         75
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT   Condition: C
FT   BINDING         78
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT   Condition: C
FT   BINDING         110
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT   Condition: C
XX
Size: 388-452;
Related: None;
Template: Q56584; A5F5Y4;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.50 2023/06/01
//