AC   MF_00440;
DC   Protein; auto
TR   HAMAP; MF_00440; -; 1; level=0
XX
Names: NrdR
XX
ID   NRDR
DE   RecName: Full=Transcriptional repressor NrdR;
GN   Name=nrdR;
XX
CC   -!- FUNCTION: Negatively regulates transcription of bacterial
CC       ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC       boxes.
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion.;
end case
CC   -!- SIMILARITY: Belongs to the NrdR family.
XX
DR   Pfam; PF03477; ATP-cone; 1; trigger=no
DR   NCBIfam; TIGR00244; TIGR00244; 1; trigger=no
DR   PROSITE; PS51161; ATP_CONE; 1; trigger=yes
XX
KW   ATP-binding
KW   DNA-binding
KW   Nucleotide-binding
KW   Repressor
KW   Transcription
KW   Transcription regulation
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
KW   Zinc-finger
end case
XX
GO   GO:0045892; P:negative regulation of DNA-templated transcription
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
XX
FT   From: NRDR_STRCO (O69980)
FT   ZN_FING         3..34
FT   Group: 1; Condition: C-x(2)-C-x(22,24)-C-x(1,2)-C
XX
Size: 140-225;
Related: None;
Template: O69980;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in MAGSA
Plasmid: in HALMD, NATPD
Comments: The ATP cone domain can be modelled using the structures for
 nrdA from E.coli, see AC P00452 and PDB cross-links therein. See also:
 [1] PubMed=15949864
 Rodionov D.A., Gelfand M.S.;
 "Identification of a bacterial regulatory system for ribonucleotide
 reductases by phylogenetic profiling.";
 Trends Genet. 21:385-389(2005).
 [2] PubMed=16950922; DOI=10.1128/JB.00903-06;
 Grinberg I., Shteinberg T., Gorovitz B., Aharonowitz Y., Cohen G.,
 Borovok I.;
 "The Streptomyces NrdR transcriptional regulator is a Zn ribbon/ATP
 cone protein that binds to the promoter regions of class Ia and class
 II ribonucleotide reductase operons.";
 J. Bacteriol. 188:7635-7644(2006).
XX
# Revision 1.39 2023/06/01
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