AC   MF_00449;
DC   Protein; auto
TR   HAMAP; MF_00449; -; 1; level=0
XX
Names: RAD50
XX
ID   RAD50
DE   RecName: Full=DNA double-strand break repair Rad50 ATPase;
GN   Name=rad50;
XX
case <OC:Halobacteria>
CC   -!- FUNCTION: Part of the Rad50/Mre11 complex, which is involved in the
CC       early steps of DNA double-strand break (DSB) repair. Rad50 controls the
CC       balance between DNA end bridging and DNA resection via ATP-dependent
CC       structural rearrangements of the Rad50/Mre11 complex.
else
CC   -!- FUNCTION: Part of the Rad50/Mre11 complex, which is involved in the
CC       early steps of DNA double-strand break (DSB) repair. The complex may
CC       facilitate opening of the processed DNA ends to aid in the recruitment
CC       of HerA and NurA. Rad50 controls the balance between DNA end bridging
CC       and DNA resection via ATP-dependent structural rearrangements of the
CC       Rad50/Mre11 complex.
end case
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per homodimer.;
CC   -!- DOMAIN: The two conserved Cys that bind zinc constitute the zinc-hook,
CC       which separates the large intramolecular coiled coil regions. The 2 Cys
CC       residues coordinate one molecule of zinc with the help of the 2 Cys
CC       residues of the zinc-hook of another Rad50 molecule, thereby forming a
CC       V-shaped homodimer.
end case
CC   -!- SUBUNIT: Homodimer. Forms a heterotetramer composed of two Mre11
CC       subunits and two Rad50 subunits.
CC   -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
XX
DR   PROSITE; PS51131; ZN_HOOK; 1; trigger=yes
DR   Pfam; PF04423; Rad50_zn_hook; 1; trigger=no
DR   Pfam; PF02463; SMC_N; 1; trigger=no
DR   General; Coiled_coil; -; 0-unlimited; trigger=yes
XX
KW   ATP-binding
KW   DNA damage
KW   DNA repair
KW   Hydrolase
KW   Nucleotide-binding
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
XX
GO   GO:0005524; F:ATP binding
GO   GO:0016887; F:ATP hydrolysis activity
GO   GO:0006302; P:double-strand break repair
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
XX
FT   From: RAD50_PYRFU (P58301)
FT   BINDING         32..38
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: N-[GA]-[SA]-G-K-[ST]-[ST]
FT   BINDING         791..796
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: [FLIM]-[LIVFM]-S-G-G-E
FT   BINDING         444
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         447
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         12
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: [RK]
FT   BINDING         140
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: Q
XX
Size: 830-1100;
Related: None;
Template: P58301;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.31 2022/11/19
//