AC   MF_00454;
DC   Protein; auto
TR   HAMAP; MF_00454; -; 1; level=0
XX
Names: FluC
XX
ID   FLUC
DE   RecName: Full=Fluoride-specific ion channel FluC;
GN   Name=fluC; Synonyms=crcB;
XX
CC   -!- FUNCTION: Fluoride-specific ion channel. Important for reducing
CC       fluoride concentration in the cell, thus reducing its toxicity.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=fluoride(in) = fluoride(out); Xref=Rhea:RHEA:76159,
CC         ChEBI:CHEBI:17051;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76160;
case <FTGroup:1>
CC   -!- ACTIVITY REGULATION: Na(+) is not transported, but it plays an
CC       essential structural role and its presence is essential for fluoride
CC       channel function.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
end case
CC   -!- SIMILARITY: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43)
CC       family.
XX
DR   Pfam; PF02537; CRCB; 1; trigger=no
DR   NCBIfam; TIGR00494; CrcB; 1; trigger=no
DR   General; Transmembrane; -; 3-7; trigger=yes
XX
case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
KW   Cell membrane
KW   Ion channel
KW   Ion transport
KW   Membrane
case <FTGroup:1>
KW   Sodium
KW   Metal-binding
end case
KW   Transmembrane
KW   Transmembrane helix
KW   Transport
XX
GO   GO:0062054; F:fluoride channel activity
GO   GO:0140114; P:cellular detoxification of fluoride
GO   GO:1903424; P:fluoride transmembrane transport
GO   GO:0005886; C:plasma membrane
XX
FT   From: FLUC_BORPE (Q7VYU0)
FT   BINDING         77
FT                   /ligand="Na(+)"
FT                   /ligand_id="ChEBI:CHEBI:29101"
FT                   /ligand_note="structural"
FT   Optional; Group: 1; Condition: G
FT   BINDING         80
FT                   /ligand="Na(+)"
FT                   /ligand_id="ChEBI:CHEBI:29101"
FT                   /ligand_note="structural"
FT   Optional; Group: 1; Condition: [TS]
XX
Size: 95-290;
Related: None;
Template: Q7VYU0; P37002; A0A0H2XLA2; B7LI20; Q5FKD2; Q5FKD1;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in BACAN, BACC1, BACCR, BACCZ, HALH5, BACHK, BACLD, SHOC1, BACSU,
 BIFLO, BRADU, BRUAB, BRUME, BRUSU, CARHZ, CLOAB, CORDI, CORGL, CORJK, DEIGD,
 DESHY, FRACC, GEOKA, HALMA, HALSA, LACAC, LACDA, LACJO, LACPL, LIGS1, LATSS,
 LEIXX, LISIN, LISMO, METAC, METBF, METH3, METMA, MOOTA, MYCBO, MYCPA, MYCTU,
 NITHX, NATPD, NOCFA, CUTAK, PROM9, PROMA, PROMM, PROMP, PROMT, RHOPB, RHOJR,
 RUBXD, STAA8, STAAB, STAAC, STAAM, STAAN, STAAR, STAAS, STAAW, STAES, STAEQ,
 STAHJ, STAS1, STRAW, STRCO, STRPN, STRR6, SYMTH, PARMW, SYNS9, SYNSC, THEFY,
 YERPE, YERPS
Plasmid: in GLUOX, PSEYM, RUEPO
Comments: Renamed the Fluc family to avoid confusion with the CLC-type F(-)/H(+) antiporters
 (see PubMed=23991286).
XX
# Revision 1.62 2023/11/28
//