AC   MF_00455;
DC   Protein; auto
TR   HAMAP; MF_00455; -; 1; level=0
XX
Names: Xylose_isom_A
XX
ID   XYLA
DE   RecName: Full=Xylose isomerase;
DE            EC=5.3.1.5;
GN   Name=xylA;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-xylose = alpha-D-xylulofuranose; Xref=Rhea:RHEA:22816,
CC         ChEBI:CHEBI:28518, ChEBI:CHEBI:188998; EC=5.3.1.5;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC       Note=Binds 2 magnesium ions per subunit.;
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the xylose isomerase family.
XX
DR   Pfam; PF01261; AP_endonuc_2; 1; trigger=no
DR   PRINTS; PR00688; XYLOSISMRASE; 1; trigger=no
DR   NCBIfam; TIGR02630; Xylose_isom_A; 1; trigger=no
DR   PROSITE; PS51415; XYLOSE_ISOMERASE; 1; trigger=no
XX
KW   Cytoplasm
KW   Isomerase
KW   Carbohydrate metabolism
KW   Xylose metabolism
KW   Magnesium
KW   Metal-binding
XX
GO   GO:0000287; F:magnesium ion binding
GO   GO:0009045; F:xylose isomerase activity
GO   GO:0042732; P:D-xylose metabolic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: XYLA_ACTM4 (P12851)
case <OC:Actinomycetales> or <OC:Deinococci>
FT   ACT_SITE        54
FT   Condition: H
FT   ACT_SITE        57
FT   Condition: [DE]
FT   BINDING         181
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Condition: E
FT   BINDING         217
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Condition: E
FT   BINDING         217
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Condition: E
FT   BINDING         220
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Condition: H
FT   BINDING         245
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Condition: D
FT   BINDING         255
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Condition: D
FT   BINDING         257
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Condition: D
FT   BINDING         292
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Condition: D
end case
FT   From: XYLA_ECOLI (P00944)
case not <OC:Actinomycetales> and not <OC:Deinococci>
FT   ACT_SITE        101
FT   Condition: H
FT   ACT_SITE        104
FT   Condition: [DE]
FT   BINDING         232
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Condition: E
FT   BINDING         268
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Condition: E
FT   BINDING         268
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Condition: E
FT   BINDING         271
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Condition: H
FT   BINDING         296
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Condition: D
FT   BINDING         307
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Condition: D
FT   BINDING         309
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Condition: D
FT   BINDING         339
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Condition: D
end case
XX
Size: 386-449;
Related: None;
Template: P12851; P12070; P54272; P00944; P15587;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in XANAC, XANC8, XANCP, XANOR
Plasmid: None
Comments: None
XX
# Revision 1.43 2023/06/01
//